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中文名称:大鼠超氧化物歧化酶1,可溶性(SOD1)酶联免疫试剂盒
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货号:CSB-EL022397RA
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规格:96T/48T
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价格:¥3600/¥2500
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其他:
产品详情
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产品描述:SOD1 (Superoxide Dismutase 1) 是一种重要的抗氧化酶,可以降解细胞内的超氧阴离子自由基,维护细胞内稳态,其高含量可提高细胞的抗氧化能力,有利于保护生物体免受氧化应激的伤害。j9九游会登录入口首页生物所提供的Rat superoxide dismutase 1, soluble (SOD1) ELISA kit属于ELISA检测试剂盒,采用双抗夹心法定量检测大鼠血清、血浆、细胞培养上清、组织匀浆样本中的SOD1,其灵敏度为3.9 pg/mL,检测范围为15.6 pg/mL-1000 pg/mL。
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别名:Sod1 ELISA Kit; Superoxide dismutase [Cu-Zn] ELISA Kit; EC 1.15.1.1 ELISA Kit
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缩写:
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Uniprot No.:
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种属:Rattus norvegicus (Rat)
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样本类型:serum, plasma, cell culture supernates, tissue homogenates
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检测范围:15.6 pg/mL-1000 pg/mL
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灵敏度:3.9 pg/mL
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Metabolism
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测定原理:quantitative
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测定方法:Sandwich
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精密度:
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
线性度:
To assess the linearity of the assay, samples were spiked with high concentrations of rat SOD1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:200 Average % 93 Range % 88-95 1:400 Average % 104 Range % 100-107 1:800 Average % 92 Range % 87-95 1:1600 Average % 97 Range % 92-100 -
回收率:
The recovery of rat SOD1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 93 89-95 EDTA plasma (n=4) 95 92-97 -
标准曲线:
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. pg/ml OD1 OD2 Average Corrected 1000 2.774 2.767 2.771 2.638 500 2.226 2.305 2.266 2.133 250 1.737 1.624 1.681 1.548 125 1.108 1.088 1.098 0.965 62.5 0.636 0.628 0.632 0.499 31.2 0.339 0.321 0.330 0.197 15.6 0.231 0.224 0.228 0.095 0 0.130 0.136 0.133 -
数据处理:
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货期:3-5 working days
引用文献
- Overexpression of macrophage migration inhibitory factor protects against pressure overload-induced cardiac hypertrophy through regulating the miR-29b-3p/HBP1 axis L Wen,Physiological reports,2024
- Promising drug candidates for the treatment of polycystic ovary syndrome (PCOS) as alternatives to the classical medication metformin HS Anbar,European journal of pharmacology,2023
- Protective effects of Althaea officinalis L. extract against N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats through antioxidative, anti-inflammatory, mitochondrial apoptosis and PI3K/Akt/mTOR signaling pathways Z Wang,Food Science & Nutrition,2023
- Diosmin mitigates dexamethasone-induced osteoporosis in vivo: Role of Runx2, RANKL/OPG, and oxidative stress ESA Arafa,Biomedicine & pharmacotherapy,2023
- Protective effects of perindopril against indomethacin-induced gastric mucosal damage through modulation of DDAH-1/ADMA and ACE-2/ANG-(1-7) signaling pathways Yasmin T. Mohamed,Drug Chem Toxicol,2021
- The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy MES Ghoneim,Toxicology and Applied Pharmacology,2020
- Alogliptin: a novel approach against cyclophosphamide-induced hepatic injury via modulating SIRT1/FoxO1 pathway RM Salama,Toxicology Research,2020
- Cinnamon Extract Ameliorates Liver Damage And Oxidative Stress Induced By Paracetamol In Male Rats H Abd El Fadil,Damanhour Journal of Veterinary Sciences,2020
- Protective effect of tanshinone IIA on H2O2-induced oxidative stress injury in rat cardiomyocytes by activating Nrf2 pathway G Yang,J. Recept. Signal Transduct. Res,2020
- Paeonol protects against hypertension in spontaneously hypertensive rats by restoring vascular endothelium Gai Z, et al,Bioscience Biotechnology and Biochemistry,2019
- Targeting AngII/AT1R signaling pathway by Perindopril inhibits ongoing liver fibrosis in rat. Abd El-Rahman SS, et al,Journal of Tissue Engineering and Regenerative Medicine,2019
- Sevoflurane reduces ischemic brain injury in rats with diet and streptozotocin-induced diabetes Zhang H,Journal of Receptors and Signal Transduction,2019
- Chlorella vulgaris ameliorates testicular toxicity induced by deltamethrin in male rats via modulating oxidative stress Osama E, et al,Andrologia,2018
- Biochemical changes in oxidative stress markers following endurance training and consumption of purslane seed in rats with hydrogen peroxide-induced toxicity Rahman Soori.et al,Sport Sciences for Health,2018
- Protective effect of pentoxifylline on oxidative renal cell injury associated with renal crystal formation in a hyperoxaluric rat model Hayrettin Ozturk.et al,Urolithiasis,2018
- Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats Una-Jovana Vajic.et al,Phytomedicine,2018
- Ebselen can Protect Male Reproductive Organs and Male Fertility from Manganese Toxicity: Structural and Bioanalytical Approach in a Rat Model Amany TharwatMohammed.et al,Biomedicine & Pharmacotherapy,2018
- A quality marker study on salvianolic acids for injection Xie YY.et al,J Sep Sci,2018
- Chitosan-coated cerium oxide nanocubes accelerate cutaneous wound healing by curtailing persistent inflammation Chun-Hua Yan.et al,Inorganic Chemistry Frontiers,2017
- Antihyperglycemic, Antidiabetic, and Antioxidant Effects of Garcinia pedunculata in Rats Md. Yousuf Ali.et al,Evidence-Based Complementary and Alternative Medicine,2017
- Hematological, biochemical, and histopathological impacts of barium chloride and barium carbonate accumulation in soft tissues of male Sprague-Dawley rats Mohammed AT.et al,Environ Sci Pollut Res Int,2017
- Novel effect of Daflon and low-dose 纬-radiation in modulation of thioacetamide-induced hepatic encephalopathy in male albino rats Abdel-Rafei M.et al,Hum Exp Toxicol.,2016
- Triptolide Protects Dopaminergic Neurons from 6-OHDA Lesion in a Rat Model of Parkinson's Disease Wenjing Zhang.et al,International Journal of Pharmacology ,2015
相关产品
靶点详情
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最新研究进展:SOD1即超氧化物歧化酶1(Superoxide dismutase 1),是重要的抗氧化酶之一。研究表明,SOD1的突变与家族性渐冻人症(Familial Amyotrophic Lateral Sclerosis,FALS)相关。最新研究发现,SOD1与白血病干细胞的维持和耐药性密切相关。此外,SOD1在肺部疾病、心脏病、肝脏疾病和癌症等多种疾病中也具有重要作用。
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功能:Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
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基因功能参考文献:
- Results provide evidence that ALS mutant SOD1 inhibits axonal transport of mitochondria by inducing PINK1/Parkin-dependent Miro1 degradation. PMID: 28973175
- SOD1 protein expression is upregulated and associated with greater oxidant production in skeletal muscle from Ts65Dn mice. PMID: 28697486
- These results suggest that the superoxide anion may be the cause of the observed oxidative damage to SOD1(G93A) rat neural tissues and that the iron-sulfur clusters may be the source of poorly liganded redox active iron implicated in ALS pathogenesis. Low temperature EPR spectroscopy appears to be a valuable tool in assessing the role of metals in neurodegenerative diseases PMID: 27130034
- SOD1 and zinc have roles in methotrexate-induced germ cell toxicity PMID: 28011267
- A motility defect in SOD1-G93A was highly correlated with mitochondrial movement. PMID: 27464601
- Diabetic testes showed decreased Nrf2, HO-1, SOD1, PCNA, and Bcl-2 expressions whereas increased COX-2, NF-kappaB, MT, IL-6, and p-ERK levels. SOD1 and GPX5 were decreased in the epididymis of diabetic rat, whereas Zn supplementation attenuated these changes. PMID: 27025721
- These findings suggest that diabetes increases lipid peroxidation and decreases SOD1 levels, and treadmill exercise can mitigate diabetes-induced oxidative damage in the hippocampus. PMID: 25293488
- The found of this study suggest that, from a histological standpoint, the SOD1-G93A rat is a valid model of ALS bulbar symptoms. PMID: 25825172
- SOD1 has sequence homology to an antihypertensive snake bradykinin-potentiating peptide. PMID: 26047849
- the knockdown of mutant SOD1 in only the motor cortex resulted in a significant delay of disease onset, expansion of lifespan, enhanced survival of spinal motor neurons,and maintenance of neuromuscular junctions PMID: 25411487
- These data extend clinical findings of a more rapid disease progression in individuals with bulbar symptoms to the SOD1-G93A rat model of ALS. PMID: 24291387
- Data suggest that expression of CuZnSOD/Sod1 (and mitochondrial MnSOD/Sod2) is down-regulated as retinal neurons undergo apoptosis following onset of diabetes/diabetic retinopathy. PMID: 24527463
- Results highlight misfolded SOD1 as common to two Amyotrophic lateral sclerosis (ALS) rodent animal models and familial ALS patient lymphoblasts with four different SOD1 mutations. PMID: 23736301
- SOD1, constitutively produced and released by microglia, is identified as an essential component of neuroprotection mediated by microglia. PMID: 22572742
- both SIRT3 and PGC-1alpha protect against mitochondrial fragmentation and neuronal cell death by mutant SOD1 PMID: 22819776
- Xanthine/xanthine oxidase treatment increases SOD1 and SOD2 protein and activity levels in cardiac progenitor cells. PMID: 22758933
- CuZn-SOD levels were increased in the hippocampus in OLETF rats. PMID: 22981416
- Data indicate that Cu-ZnSod expression decreased upon long reperfusion and trxr1 expression did not vary. PMID: 22377061
- Data show that aging is associated with reduction in superoxide dismutase (SOD) Cu/Zn-SOD protein expression and total SOD enzymatic activity in mesenteric lymphatic vessel (MLV). PMID: 22540739
- Cu/Zn-SOD activity was not significantly changed in response to vitamin E administration at any time points, whereas Cu/Zn-SOD mRNA levels were significantly increased after longer time points with high doses (30 and 100 mg/kg) of vitamin E. PMID: 22732938
- The increased expression of antioxidant SOD1, specifically in hippocampal neurons, will provide protection from age-related cognitive decline. PMID: 21942371
- dehydroepiandrosterone treatment did not alter disease progression or survival in SOD1-G93A rats PMID: 22409357
- Using gastrocnemius muscles of mice overexpressing human mutant SOD1 (mutSOD1) at different disease stages. PMID: 22178654
- expression of Cu,Zn-superoxide dismutase decreased significantly in the dorsal hippocampus (CA1 and CA2) and tended to decrease in ventral regions (CA3 and dentate gyrus) by the 24th hour after 3-fold exposure to hypoxia. PMID: 22451871
- The present results suggested that inhibition of Shh signaling pathway exacerbated rat ischemic damage caused by pMCAO, which may be correlated with down-regulated expression of Gli1, Ptch1 and SOD1. PMID: 22133807
- Data have shown that different stressors have diverse effect on hepatic CuZnSOD and MnSOD activity as well as on serum CORT level. PMID: 21625958
- Thus mitochondrial dysfunction is a key early element in pathogenesis of motor neuron degeneration in transgenic SOD1 rats PMID: 21745570
- rat Cu/Zn SOD can be nitrated, a modification that could lead to the depressed activity of this enzyme found in placentas from diabetic rats PMID: 20815790
- Results describe changes in SOD1 immunoreactivity associated with lipid peroxidation and inflammatory responses in the hippocampi of STZ-induced type I diabetic rats. PMID: 20924670
- most, but not all, properties of SOD1 remain the same with a GFP tag PMID: 20221404
- Cu,Zn-superoxide dismutase increases toxicity of mutant and zinc-deficient superoxide dismutase by enhancing protein stability PMID: 20663894
- Data indicate that acute and/or chronic stress models have different degrees of influence on serum corticosterone and copper-zinc/manganese superoxide dismutase subcellular protein levels. PMID: 20020182
- A significant reduction of Cu,Zn-Sod-1 activity level is observed during fast speed running in the crural diaphragm muscle. PMID: 20134035
- results suggest that mutant SOD1 and defective mitochondria create localized dysfunctional domains in motor axons, which may lead to progressive axonopathy in ALS PMID: 19344250
- Transcriptional regulation and environmental induction of gene encoding copper- and zinc-containing superoxide dismutase. PMID: 11912919
- Levels of Sod1 mRNA were significantly reduced in congestive heart failure following myocardial infarction. PMID: 14575298
- Associated with copper deficiency were consistent reductions in immunoreactive SOD in erythrocytes. PMID: 15337829
- Medroxyprogesterone acetate inhibits the effect of idarubicin on blood levels of this enzyme. PMID: 15372991
- the role of PPARgamma is specific to events occurring during reperfusion, in which to CuZn-SOD is a mediator of neuroprotection PMID: 15618443
- respiratory motor neuron loss results in significant electrophysiologic changes and diaphragmatic atrophy in SOD1 G93A rats PMID: 16084734
- mutant superoxide dismutase has a role in experimental amyotrophic lateral sclerosis PMID: 16195234
- Overexpression of SOD1 in whole lens prevents H2O2-induced oxidative damage (cataract formation) to the lens and subsequent control of gap junctions by protein kinase Cgamma. PMID: 16254550
- Levels are not significantly altered in the rat prostate during aging and thus is unlikely to be an important factor in the evolution of epithelial cell hyperplasia. PMID: 16372329
- These findings show a heterogeneous expression of Cu/Zn SOD in restricted cell types in the germinative zones and suggest a role for antioxidant Cu/Zn SOD in progenitor cells of the immature rat brain. PMID: 16567040
- We hypothesized that LA might induce dissociation of p56(Lck) from CD4, thus leading to its downmodulation. PMID: 16631605
- In conclusion, this study demonstrates an age-related decline in Cu/Zn-SOD and IDO activities, the two enzymes responsible for scavenging O2*-. PMID: 16688932
- acute and rapid endothelial cell endocytosis of CuZn-SOD, possibly via activation of a receptor-mediated pathway PMID: 17077646
- EcSOD, CuZnSOD, catalase, and MMP-2 mRNA expression did not statistically vary between aortic aneurysm and normal tissue PMID: 17196988
- Ischemic attack causes a rapid response in hippocampal tissue as well as in the cerebrospinal fluid, represented by an increase in the activity of endogenous antioxidant enzymes SOD and CAT. PMID: 17215005
- Data show that activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo. PMID: 17324120
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亚细胞定位:Cytoplasm. Nucleus.
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蛋白家族:Cu-Zn superoxide dismutase family
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数据库链接:
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