Mouse Bone morphogenetic protein 2,BMP-2 ELISA Kit

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation.

1. TNAP activation in vascular smooth muscle cells (VSMCs) appears sufficient to induce calcification. TNAP activation in VSMCs stimulates expression of chondrocyte markers. PMID: 27932058
2. widespread myocardial Bmp2 and endocardial Notch signaling drive presumptive ventricular endocardium to differentiate into valve endocardium PMID: 29853617
3. BMP-2 can enhance HUVEC proliferation, migration and angiogenesis through P38, ERK and Akt/m-TOR pathway. PMID: 27886213
4. CTGF and BMP2 are induced following myocardial ischemia in mice and humans. PMID: 28460577
5. Results indicate that Notch signaling induces cell cycle arrest and thereby initiates chondrocyte cell enlargement via bone morphogenetic protein 2 (BMP2) signaling. PMID: 27146698
6. Collectively, our findings indicate that CBFA2T2 is required for BMP-2-induced osteogenic differentiation of MSCs through inhibition of EHMT1-mediated histone methylation at Runx2 promoter. PMID: 29378183
7. The data suggest that SDF-1beta provides synergistic effects supporting BMP-2-induced, BMSC-mediated bone formation and appears suitable for optimization of bone augmentation in combination therapy protocols. PMID: 26227988
8. study revealed that only BMP-6 was able to induce bone formation at the used dose and that the addition of IGF-1 contributed to an increase of the mineralization in the implants. Hence, the combination of BMP-6 with IGF-1 might be a better alternative than BMP-2 for orthopedic surgery or bone tissue engineering approaches. PMID: 28256809
9. BMP2 may induce osteogenic differentiation. PMID: 28395271
10. Increased bone mass in Crmp4(-/-) mice was associated with enhanced BMP2 signaling and BMP2-induced osteoblast differentiation in Crmp4(-/-) osteoblasts (OBs). PMID: 28019696
11. Deletion of the "ultra-conserved sequence" within the 3'UTR of the Bmp2 was associated with elevated Bmp2 mRNA and BMP signaling levels, reduced fitness, and embryonic malformations. PMID: 28401685
12. miR-106b inhibited osteoblastic differentiation and bone formation partly through directly targeting bone morphogenetic protein 2. PMID: 28108317
13. cells stimulated with BMP-2 in the presence of FBS require the phosphorylation of Akt at Ser473 and the dephosphorylation of Akt at Thr308 to increase the osteoblast differentiation with alkaline phosphatase activity similar to that of BMP-9 plus FBS. PMID: 27477105
14. This study showed that release of BMP-2 and SDF-1alpha from heparinized MCM scaffolds allows for the reduction of the applied BMP-2 concentration since SDF-1alpha seems to enhance the osteoinductive potential of BMP-2. PMID: 27060915
15. mice implanted with sulfonated PRX/BMP-2 complexes exhibited rapid and significant bone regeneration compared to those implanted with free BMP-2 and heparin/BMP-2 complexes. PMID: 28130833
16. these data demonstrate that in addition to BMP6, endothelial cell BMP2 has a non-redundant role in hepcidin regulation by iron. PMID: 28815688
17. results indicate that Alx3 expression is enhanced by BMP-2 via the BMP receptors mediated-Smad signaling and that Alx3 is a positive regulator of osteoblast differentiation induced by BMP-2 PMID: 23825702
18. KDM5A-mediated H3K4me3 modification participated in the etiology of osteoporosis and may provide new strategies to improve the clinical efficacy of BMP2 in osteoporotic conditions. PMID: 27512956
19. BMP2 expression in the endocardial lineage is essential for the distal outgrowth, maturation and remodeling of atrioventricular endocardial cushions. PMID: 28790014
20. the effect of titanium (Ti) with nanotopography (Nano) on the endogenous expression of BMP-2 and BMP-4 and the relevance of this process to the nanotopography-induced osteoblast differentiation. PMID: 26681207
21. Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling PMID: 27113717
22. can increase [Ca(2+) ]i through extracellular calcium influx regulated by FAK and ALP and can deplete endoplasmic reticulum calcium through Src signaling simultaneously PMID: 26890302
23. Our studies suggest operation of an auto/paracrine mechanism by which BMP-2 secreted by M1 macrophages maintains constitutive activation of a BMP-2 receptor/SMAD1/5 signaling axis. PMID: 28711495
24. Genetic inactivation of hepatic angiocrine Bmp2 signaling in Stab2-Cre mice caused massive iron overload in the liver and increased serum iron levels and iron deposition in several organs similar to classic hereditary hemochromatosis; these changes were mediated by decreased hepatic expression of hepcidin, a key regulator of iron homeostasis. PMID: 27903529
25. Actin cytoskeleton depolymerization inhibites BMP2 signaling via blocking of Smad by dephosphorylated CNN1 in osteoblast cells under simulated microgravity. PMID: 28457943
26. Thus, our findings identify an unrecognized function of neogenin in mouse neocortical astrocyte differentiation, and suggest a signaling pathway, BMP2-neogenin-YAP-Smad1, underlying astrogliogenesis in developing mouse neocortex. PMID: 27225772
27. These results suggest that BMP-2 directly induces Ifrd1 expression at the transcriptional level in osteoblasts via the Smad pathway, and Ifrd1 negatively regulates BMP-2-dependent osteoblastogenesis. PMID: 27856249
28. By suppressing BMP2 signaling the adverse effects of excessive inflammation after myocardial infarction are limited. PMID: 27283840
29. Western blot analysis demonstrated that following BMP2 and BMP7 cotransfection of MC3T3E1 cells, the protein expression levels of BMP2, BMP4, BMP6, BMP7, BMP9 and Wnt3a were increased compared with control cells PMID: 27633082
30. treatment of mBMSCs with the selective inhibitor of NF-kappaB pathway, BAY11-770682, showed to retrieve the inhibitory effect of CM-Adipo on BMP2-induced osteoblast differentiation in mBMSCs. PMID: 28173811
31. BetA can enhance in vivo osteogenic potentials of BMP2, possibly via stimulating Smad 1/5/8 and p38 pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases. PMID: 27188281
32. Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1-Smad5-Smad8 phosphorylation. PMID: 27030100
33. Combining VEGF165 obviously enhanced the inducing effects of BMP2 on osteogenic differentiation capacity of C3H10T1/2 cells. PMID: 26757978
34. Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation. PMID: 26635037
35. Studied the effect of 7-dehydrocholesterol reductase (Dhcr7) and identified signal pathways involved in regulation of embryonic palatogenesis. Expression changes of Dhcr7, Sonic Hedgehog (Shh), and bone morphogenetic protein-2 (Bmp2) were measured by RT-PCR and WB after Dhcr7 gene silencing and the addition of exogenous cholesterol. PMID: 27066502
36. A specific conserved AU-rich element within the Bmp2 ultra-conserved sequence was directly bound by the activating protein HuR. PMID: 26212702
37. Mesenchymal Stem Cells Within Gelatin/CaSO4 Scaffolds Treated Ex Vivo with Low Doses of BMP-2 and Wnt3a Increase Bone Regeneration. PMID: 26414873
38. Following fracture, a CXCL12(+)-BMP2(+) perivascular cell population is recruited along the endosteum. PMID: 25967044
39. Cyclic stretch enhanced the BMP-2induced osteoblastic differentiation through the inhibition of Hey1. PMID: 26647760
40. Regulatory effects of fibroblast growth factor-8 and tumor necrosis factor-alpha on osteoblast marker expression induced by bone morphogenetic protein-2. PMID: 26409788
41. assessed the role of BMP2 expression globally, by osteoblasts, and by vascular endothelial cells in endochondral healing, intramembranous healing and lamellar bone formation PMID: 26344756
42. Combination of bone morphogenetic protein-2 plasmid DNA with chemokine CXCL12 creates an additive effect on bone formation PMID: 26214286
43. these results suggest that the recently described nuclear variant of BMP2 is necessary for efficient secondary immune responses. PMID: 26491697
44. only BMP7, not BMP2 or BMP4, is necessary for interdigital programmed cell death PMID: 26826495
45. Gremlin blocks BMP2 signaling and function in pancreatic stellate cells in vitro PMID: 26141517
46. These results demonstrated that the cotransfection of BMP-2 and VEGF into microencapsulated C2C12 cells is of potent utility for the potentiation of bone regeneration. PMID: 26451370
47. alphavbeta3 integrin is required to mediate BMP-2-induced Smad signaling. PMID: 26953352
48. Report phenotype of BMP2/4 double knockout osteoblast cell line. PMID: 26595646
49. integrin alpha1beta1/BMPR IA may block BMP-2/BMPR IA complex information and interfere with the BMP-2 signalling pathway in cells PMID: 26475222
50. Decreased expression of Osterix, as well as impaired TGFbeta and BMP2 signaling, contribute to the observed osteopenic bone phenotype of TIEG1 KO mice. PMID: 26801561

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Secreted.

TGF-beta family

KEGG: mmu:12156

STRING: 10090.ENSMUSP00000028836

UniGene: Mm.103205