Your Good Partner in Biology Research

  1. 首页
  2. 试剂盒
  3. 酶联免疫试剂盒
  4. Rat Retinol binding protein 4,RBP-4 ELISA Kit

Rat Retinol binding protein 4,RBP-4 ELISA Kit

  • 中文名称：
    大鼠视黄醇结合蛋白4(RBP-4)酶联免疫试剂盒
  • 货号：
    CSB-E09424r
  • 规格：
    96T/48T
  • 价格：
    ￥3900/￥2500
  • 其他：

产品详情

  • 产品描述：
        RBP4（全称Retinol-binding protein 4）是一种负责维生素A转运和代谢的血清蛋白，主要由肝脏合成。其含量水平与多种疾病相关，如糖尿病、肥胖、代谢综合征等。研究表明，RBP4可影响胰岛素抵抗、葡萄糖代谢以及脂肪代谢等生理过程，因此被认为是一种潜在的治疗靶点。
        j9九游会登录入口首页生物所提供的Rat Retinol binding protein 4,RBP-4 ELISA Kit属于ELISA检测试剂盒，采用竞争法定量检测大鼠血清、血浆、组织匀浆样本中的RBP4，其灵敏度为39 ng/ml.，检测范围为39 ng/ml-2500 ng/ml.。
     
  • 别名：
    Rbp4 ELISA Kit; Retinol-binding protein 4 ELISA Kit; Plasma retinol-binding protein ELISA Kit; PRBP ELISA Kit; RBP ELISA Kit
  • 缩写：
  • Uniprot No.：
  • 种属：
    Rattus norvegicus (Rat)
  • 样本类型：
  • 检测范围：
  • 灵敏度：
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Signal Transduction
  • 测定原理：
    quantitative
  • 测定方法：
    Competitive
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 最新研究进展：
    RBP4是一种在维生素A代谢中起关键作用的蛋白质，但它也与一些代谢性疾病如肥胖、糖尿病和代谢综合征等有关。一些最新的研究表明，RBP4可能作为这些疾病的潜在生物标志物和治疗靶点，有望为相关疾病的治疗提供新的思路和策略。
  • 功能：
    Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane.
  • 基因功能参考文献：
    1. RBP4 levels increased by 2-fold in the serum of nonobese Goto-Kakizaki rats but not high-fat diet fed rats. PMID: 26923513
    2. plasma RBP4 concentrations were associated with cardiovascular disease. In addition, RBP4 increases the proliferation of vascular smooth muscle cells induced by hyperinsulinism via activation of MAPK signaling pathway PMID: 24888764
    3. Retinol binding protein 4 promotes hyperinsulinisminduced proliferation of rat aortic smooth muscle cells. PMID: 24604418
    4. Decreased trophoblast expression of retinol transport proteins suggest that nitrofen may interfere with the fetal retinol transport resulting in reduced pulmonary RBP and TTR levels and causing pulmonary hypoplasia in CDH. PMID: 22015466
    5. Steatotic liver grafts are more predisposed to down-regulate retinol-binding protein 4 and overexpress proliferator-activated receptor-gamma. PMID: 21487070
    6. RBP4 contributes to the pathogenesis of insulin resistance in spontaneously hypertensive rats. PMID: 21365528
    7. Increases in RBP4 or Nampt/visfatin do not accompany obesity and insulin resistance in the models examined. PMID: 18401839

    显示更多

    收起更多

  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Calycin superfamily, Lipocalin family
  • 组织特异性：
    Detected in blood plasma (at protein level).
  • 数据库链接：