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GABBR2 Antibody

  • 中文名称：
    GABBR2兔多克隆抗体
  • 货号：
    CSB-PA009135ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GABBR2 Polyclonal antibody
  • Uniprot No.：
    O75899
  • 基因名：
  • 别名：
    BcDNA:GH07312 antibody; CG6706 antibody; CT20836 antibody; D Gaba2 antibody; FLJ36928 antibody; G protein coupled receptor 51 antibody; G-protein coupled receptor 51 antibody; GAB B R2 antibody; GABA B R2 antibody; GABA B receptor 2 antibody; GABA-B receptor 2 antibody; GABA-B-R2 antibody; GABA-BR2 antibody; GABAB R2 antibody; GABABR 2 antibody; GABABR2 antibody; GABB R2 antibody; GABBR 2 antibody; Gabbr2 antibody; GABR2_HUMAN antibody; Gamma aminobutyric acid B receptor 2 antibody; Gamma aminobutyric acid GABA B receptor 2 antibody; Gamma aminobutyric acid type B receptor subunit 2 antibody; Gamma-aminobutyric acid type B receptor subunit 2 antibody; Gb 2 antibody; Gb2 antibody; GH07312 antibody; GPR 51 antibody; GPR51 antibody; GPRC 3B antibody; GPRC3B antibody; HG 20 antibody; HG20 antibody; HRIHFB2099 antibody; Metabotropic GABA B receptor subtype 2 antibody; OTTHUMP00000021776 antibody; OTTHUMP00000063797 antibody; R2 SUBUNIT antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Gamma-aminobutyric acid type B receptor subunit 2 protein (60-310AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).
  • 基因功能参考文献：
    1. GABA B receptor expression in myometrium PMID: 30343129
    2. We demonstrated that GABBR2 gene might be a novel potential epigenetic treatment target with induction erlotinib treatment for stage IIIa (N2) EGFR 19 deletion lung adenocarcinoma PMID: 28490462
    3. There was no statistically significant association for the two SNPs of the GABBR1 gene (rs29230 and rs29267). However, a significant difference between AUD individuals and controls was observed at genotype level for rs2900512 of GABBR2 gene. PMID: 28118741
    4. Missense Mutation in GABBR2 gene is associated with Neurodevelopmental Disorders. PMID: 28867141
    5. GABBR2 is a genetic factor that determines Rett syndrome- or epileptic encephalopathy-like phenotype expression depending on the variant positions. GABBR2-mediated gamma-aminobutyric acid signaling is a crucial factor in determining the severity and nature of neurodevelopmental phenotypes. PMID: 28856709
    6. Using a ligand-guided approach, eight GABAB2 homology models have been chosen as possible structural representatives of the transmembrane domain of the GABAB2 subunit. PMID: 28323850
    7. a GABBR2 variant, predicted to be disease-causative, was significantly associated with corticospinal excitability at corrected levels. A subsequent uncorrected exploratory analysis revealed associations between GABBR2, GABRA2 and DRD2 variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset. PMID: 27033668
    8. The rare variants in GABBR2 were significantly associated with smoking status. PMID: 25450229
    9. GABBR2 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2+)]i via a Gi/o-coupled receptor pathway and a phospholipase C activation pathway. PMID: 24682435
    10. Putative GABAA and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex. PMID: 24923912
    11. The endoplasmic reticulum retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation. PMID: 24778228
    12. gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity PMID: 24482233
    13. and GABABR2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities. PMID: 22169202
    14. Results show that GABA(B) receptors R1 and R2 must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA. PMID: 22613715
    15. The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptor that is unique to the GABAergic system. PMID: 22660477
    16. The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 and GABBR2 genes. PMID: 21971078
    17. Gamma-aminobutyric acid type B (GABA(B)) receptor internalization is regulated by the R2 subunit. PMID: 21724853
    18. The results of this study provided evidence of Gabbr2 Deficit in schizophrenia and mood disorders. PMID: 21303731
    19. GABA(B) receptor subunit 2 levels are significantly decreased in the cingulate cortex and fusiform gyrus of autism patients compared to controls. PMID: 20557420
    20. variants of GABBR1 and GABBR2 are associated with nicotine dependence in European- and African-American populations PMID: 19763258
    21. Increased expression of GABA(B) receptor subtype 2 indicates augmented presynaptic inhibition of glutamate release as a possible protective mechanism in temporal lobe epilepsy. PMID: 14625043
    22. GABA(B) receptor subunit GABA(B)R2 is found on the same neurons and follows the same distribution patterns in the basal ganglia as the GABABR1 receptor subunit. PMID: 14961561
    23. Association of the GABA(B)R1 with the GABA(A) receptor gamma2S subunit robustly promotes cell surface expression of GABA(B)R1 in the absence of GABA(B)R2, that is usually required for efficient trafficking of GABA(B)R1 to the cell surface. PMID: 14966130
    24. The GABA(B) receptor may be present as a heterodimer with subunits of GABA(B1) and GABA(B2) in the human colon. PMID: 14978362
    25. Functional GABA(B) receptors are expressed in human airway smooth muscle cells PMID: 16829628
    26. GABA(B) receptor stability and signaling can be modulated via GABA(B) receptor subunit 2 interactions with the PDZ scaffold protein Mupp1, which may contribute to cell-specific regulation of GABA(B) receptors in the central nervous system. PMID: 17145756
    27. Levels of GABBR1 are significantly decreased in the cerebellum of patients with autism. PMID: 19002745

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family, GABA-B receptor subfamily
  • 组织特异性：
    Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in hear
  • 数据库链接：

    HGNC: 4507

    OMIM: 607340

    KEGG: hsa:9568

    STRING: 9606.ENSP00000259455

    UniGene: Hs.198612