ITGAE Antibody

1. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. PMID: 30006565
2. Pxn binding to the CD103 cytoplasmic tail triggers alphaEbeta7 integrin outside-in signaling that promotes CD8(+) T-cell migratory behavior and effector functions. PMID: 29021139
3. The CD103+CD4+/CD4+ ratio does not accurately discriminate between sarcoidosis and other causes of lymphocytic alveolitis, neither alone nor in combination with the CD4+/CD8+ ratio, and is not a powerful marker for the diagnosis of sarcoidosis. PMID: 27230039
4. CD103 expression in human dendritic cells is regulated differentially by retinoic acid and Toll-like receptor ligands. PMID: 28087652
5. detected CD103 tumor cells in 41% (16/39) of lymph node-involved adult T-cell leukemia/lymphoma PMID: 26813744
6. Levels of GZMA and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients. PMID: 26522261
7. PD-1(+)CD103(+) CD8 TIL might regain functional antitumor activity, an effect that potentially could be augmented by immune modulation. PMID: 25957117
8. This report highlights the diagnostic difficulties and the need of consensus in categorizing clonal CD103(+) lymphocytosis in patients with refractory celiac disease. PMID: 25637255
9. Cell-sorting experiments demonstrated that IDO1 expression is found in a subset of CD1a(+)CD14(-)langerin(+) cells, expressing CD103 PMID: 25584868
10. Report CD103 expression occurs most frequently in gastrointestinal T-cell lymphomas. PMID: 25025448
11. Tumor-infiltrating lymphocytes expressing the tissue resident memory marker CD103 are associated with increased survival in high-grade serous ovarian cancer. PMID: 24190978
12. Using a human CTL system model based on a CD8(+)/CD103(-) T cell clone specific of a lung tumor-associated Ag, we demonstrated that the transcription factors Smad2/3 and NFAT-1 are two critical regulators of this process. PMID: 24477908
13. Memory CD103+ CD8 T cells that persist within the brain after an acute infection with vesicular stomatitis virus are bona fide tissue resident memory cells. PMID: 22922816
14. Lymphoid tissue (LT)-resident CD8alpha-positive dendritic cells (DCs) and non(LT)-derived CD103-positive DCs express transgenic XCR1 and are characterized by a unique transcriptional fingerprint, irrespective of their tissue of origin. PMID: 21948982
15. These findings support the usefulness of CD123 and CD103 to aid in the differential diagnosis of B-cell lymphoproliferative disorders PMID: 21917686
16. Studies indicate that the mechanisms that regulate the retention of tissue-resident memory T cells include TGF-beta-mediated induction of CD103 and downregulation of CCR7. PMID: 21739671
17. results show that binding of the human alphaE I domain to oral and skin keratinocytes is independent of E-cadherin PMID: 20875079
18. has a role in mucosal immunity and graft rejection PMID: 12370249
19. Involvement of the adhesive ligand pair CD103-E-cadherin in human thymocyte cell proliferation PMID: 12414996
20. Differential up-regulation of CD103 expression on lamina propria lymphocytes in Crohn's disease may indicate differential humoral or cellular regulation in inducing CD103 molecules on lymphocytes in patients with this disease PMID: 14532999
21. CD103 promotes destruction of renal allografts by CD8 T cells PMID: 15196058
22. Integrin/activation marker CD103 (alphaEbeta7) is expressed on Epstein-Barr virus-specific tonsil-resident (but not peripheral blood mononuclear leukocyte-derived) cytotoxic T lymphocytes. PMID: 16177076
23. CD103 expression on dendritic cells influences the balance between effector and regulatory T cell activity in the intestine. PMID: 16216886
24. human alloantigen-induced CD103+ CD8+ T cells possess functional features of regulatory T cells PMID: 16920912
25. CD8+/CD103+ tumor-reactive T lymphocytes infiltrating epithelial tumors most likely play a major role in antitumor cytotoxic response through alphaEbeta7-E-cadherin interactions. PMID: 17325197
26. An investigation to evaluate the diagnostic value of relative number of CD103 expressing CD4(+) T-lymphocytes in the BAL fluid of patients with a variety of interstitial lung diseases, including pulmonary sarcoidosis, is reported. PMID: 18182176
27. integrin alpha(E)(CD103)beta(7) is not only involved in epithelial retention, but also in shaping and proper intraepithelial morphogenesis of some leukocytes. PMID: 18492951
28. Phenotypic analysis of peripheral blood and decidual CD8+ T cells showed the presence of activated CD8+ T cells as well as a population of CD8+CD103+ T cells in decidual tissue PMID: 19150377
29. A higher proportion of CD103+CD4+ T cells and ITGAE -1088 AA genotype might be associated with fibrosis formation in pulmonary sarcoidosis. PMID: 19604725

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HGNC: 6147

OMIM: 604682

KEGG: hsa:3682

STRING: 9606.ENSP00000263087

UniGene: Hs.513867