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  4. Recombinant Human Erythrocyte band 7 integral membrane protein (STOM)

Recombinant Human Erythrocyte band 7 integral membrane protein (STOM)

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  • 中文名称：
    人STOM重组蛋白
  • 货号：
    CSB-EP022862HU
  • 规格：
    ￥1836
  • 促销：
    现货重组蛋白特价促销
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    BND7 ; EPB7 ; EPB72; Erythrocyte band 7 integral membrane protein; Erythrocyte membrane protein band 7.2 (stomatin) ; Erythrocyte surface protein band 7.2; Protein 7.2b; STOM; STOM_HUMAN; Stomatin
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    47.7kDa
  • 表达区域：
    1-288aa
  • 氨基酸序列
    MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
  • 基因功能参考文献：
    1. we show that stomatin modulates the transport activity of AE1 through a direct protein-protein interaction. PMID: 28387307
    2. These results may suggest that stomatin is a new prognostic indicator for HER2-positive breast cancer PMID: 27577936
    3. FRAP analyses indicate that the stomatin C-terminus is the dominant entity for lateral mobility and binding site for the cortical actin cytoskeleton PMID: 28575093
    4. This study showed that cells expressing more stomatin or exposed to exogenous stomatin are more prone to undergoing cell fusion; during osteoclastogenesis, depletion of stomatin inhibited cell fusion but had little effect on tartrate-resistant acid phosphatase production. PMID: 27663861
    5. s took a proteomic approach to identify stomatin, a member of the integral proteins of lipid rafts, as a cellular protein interacting with hepatitis C virus NS5B. PMID: 25262680
    6. Stomatin protein expression is down-regulated in 80% of non-small cell lung cancer samples. PMID: 24533441
    7. upregulation of stomatin by hypoxia and dex may enhance the barrier function of alveolar epithelia and mediate the adaptive role of glucocorticoid to hypoxia PMID: 23672602
    8. Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains PMID: 23219802
    9. [review] Stomatin family member STOM is oligomeric; it localizes mostly to membrane domains and has been shown to modulate ion channel activity. PMID: 21501885
    10. The study indicates that stomatin, sorcin, and synexin are echinophilic membrane components that mainly locate outside GM1 rafts in the human erythrocyte membrane. PMID: 20858460
    11. This study demonstrated the existence of alpha-granular lipid rafts and suggests an important role for stomatin in the organization and function of alpha granules. PMID: 12130500
    12. stomatin is localized to detergent-insoluble domains of neutrophil granule membranes PMID: 12429719
    13. in stomatocytosis there is no significant abnormality in stomatin gene sequence instead, deficiency of stomatin from red cells appears to be due to a loss of stomatin from these red cells on maturation in the bone marrow and in the circulation. PMID: 12750157
    14. study of strongly homologous stomatin-like genes in prokaryotes reveals a close connection with a gene coding for a hydrophobic protein with a probable serine protease motif; stomatin could be a partner protein for a membrane-bound proteolytic process PMID: 15121101
    15. stomatin binds to and alters the gating of acid-sensing ion channels PMID: 15471860
    16. A small C-terminal region of stomatin that is largely hydrophobic (residues 264-272) is crucial for oligomerization, whereas the N-terminal domain (residues 1-20) and the last 12 C-terminal amino acids (residues 276-287) are not essential. PMID: 16766530
    17. The stomatin-actin association is important in maintaining the structure and in modulating the function of stomatin-containing membrane rafts in red cells. PMID: 17961506
    18. Data indicate that a stomatin-specific, raft-based process is involved in storage-associated vesiculation. PMID: 18067507
    19. Stomatin-like protein-1 interacts with stomatin and is targeted to late endosomes PMID: 19696025
    20. Stomatin is a member of an ancient protein family that has extremely well conserved homologues in all three domains of life. PMID: 18267007

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor; Cytoplasmic side. Membrane raft. Melanosome. Cytoplasmic vesicle.
  • 蛋白家族：
    Band 7/mec-2 family
  • 组织特异性：
    Detected in erythrocytes (at protein level). Widely expressed.
  • 数据库链接：

    HGNC: 3383

    OMIM: 133090

    KEGG: hsa:2040

    STRING: 9606.ENSP00000286713

    UniGene: Hs.253903