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  4. Recombinant Mouse Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (Plod2)

Recombinant Mouse Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (Plod2)

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  • 中文名称：
    小鼠Plod2重组蛋白
  • 货号：
    CSB-EP886417MO
  • 规格：
    ￥2328
  • 促销：
    现货重组蛋白特价促销
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Plod2; Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; EC 1.14.11.4; Lysyl hydroxylase 2; LH2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    85.0 kDa
  • 表达区域：
    26-737aa
  • 氨基酸序列
    VAEETPGRIPADKLLVITVATKENDGFHRFMNSAKYFNYTVKVLGQGQEWRGGDGMNSIGGGQKVRLLKEAMEHYASQEDLVILFTECFDVVFAGGPEEVLKKFQKTNHKIVFAADGLLWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYISRLVQQWNLQDNDDDQLFYTKVYIDPLKREAFNITLDHKCKIFQALNGATDEVVLKFENGKSRVKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQENGCALCDVDTIDLSTVDVPPKVTLGVFIEQPTPFLPRFLNLLLTLDYPKEALQLFIHNKEVYHEKDIKVFVDKAKHDISSIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLTNPRTLKFLIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGIWNVPYMANVYLIQGKTLRSEMNERNYFVRDKLDPDMALCRNARDMGVFMYISNRHEFGRLISTANYNTSHLNNDFWQIFENPVDWKEKYINRDYSKIFTENIVEQPCPDVFWFPIFSERACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQIGLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    C-terminal 6xHis-Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
  • 基因功能参考文献：
    1. FKBP65 regulates LH2-mediated collagen cross-linking. PMID: 28378777
    2. The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology. PMID: 27803159
    3. s propose that lysyl hydroxylase 2, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental osteoarthritis. PMID: 23069856
    4. Lysyl hydroxylase-2b directs collagen cross-linking pathways through its action on telopeptidyl lysine residues. PMID: 15231023
    5. LH2b catalyzes post-translational modification of collagen in collagen matrix formation and mineralization in bone. PMID: 15619673
    6. analysis of the specific regulation for the expression of LH isoforms as well as for alternative splicing of LH2 during embryogenesis and in different tissues PMID: 16996725

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  • 亚细胞定位：
    Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
  • 组织特异性：
    Is highly expressed in the heart, lung, kidney, eye, ovary and placenta.
  • 数据库链接：

    KEGG: mmu:26432

    STRING: 10090.ENSMUSP00000125373

    UniGene: Mm.79983