ALDH1A3
ALDH1A3，即乙醛脱氢酶家族1成员A3，别名ALDH1A3。它是一种在人体中由ALDH1A3基因编码的酶，主要参与视黄醛的代谢过程，将视黄醛氧化为视黄酸，这一过程对于维持细胞内视黄酸稳态和调节细胞分化至关重要。ALDH1A3在多种组织中都有表达，尤其是在干细胞和肿瘤干细胞中表达较高，其异常表达与多种肿瘤的发生发展有关，包括胶质母细胞瘤、胰腺癌等。ALDH1A3的作用机制涉及到其催化活性，它能够将视黄醛转化为视黄酸，影响细胞的增殖和分化。此外，ALDH1A3还可能参与调节其他细胞内信号传导通路，如JAK/STAT3通路，影响肿瘤细胞的侵袭能力。在肿瘤干细胞中，ALDH1A3的高表达与肿瘤的自我更新、多向分化潜能以及肿瘤起始能力密切相关，是维持肿瘤干细胞特性的关键分子。ALDH1A3的生物学意义主要体现在其对肿瘤干细胞特性的调控作用。研究发现，ALDH1A3的表达水平与肿瘤的侵袭性、转移能力以及对治疗的抵抗性有关。例如，在胶质母细胞瘤干细胞中，ALDH1A3的高表达与肿瘤的自我更新和致瘤性相关；在胰腺癌中，ALDH1A3的表达水平升高与肿瘤的侵袭能力增强有关。因此，ALDH1A3被认为是肿瘤治疗的潜在靶点，针对其活性或表达水平的干预可能为肿瘤治疗提供新的策略。
热销产品
Recombinant Human Aldehyde dehydrogenase family 1 member A3 (ALDH1A3) (CSB-YP001567HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ALDH1A3 Antibody (CSB-PA001567LA01HU)
验证数据
Western Blot
Positive WB detected in: U87 whole cell lysate, Mouse liver tissue
All lanes: ALDH1A3 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57 kDa
Observed band size: 57 kDa
Immunofluorescent analysis of PC-3 cells using CSB-PA001567LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
ALDH1A3 Antibodies
ALDH1A3 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA001567LA01HU | ALDH1A3 Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-PA001567LC01HU | ALDH1A3 Antibody, FITC conjugated | Human |
ALDH1A3 Proteins
ALDH1A3 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP001567HU | Recombinant Human Aldehyde dehydrogenase family 1 member A3 (ALDH1A3) | Yeast |
| CSB-EP001567HU | Recombinant Human Aldehyde dehydrogenase family 1 member A3 (ALDH1A3) | E.coli |
| CSB-BP001567HU CSB-MP001567HU CSB-EP001567HU-B |
Recombinant Human Aldehyde dehydrogenase family 1 member A3 (ALDH1A3) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
