FAP

FAP，即成纤维细胞激活蛋白，别名Fibroblast Activation Protein-α、FAP-α。它是一种II型跨膜丝氨酸蛋白酶，通常在正常组织中表达量很低，但在纤维化、关节炎和癌症等病理性疾病中表达显著升高。FAP的作用机制包括促进肿瘤细胞的增殖、侵袭、血管生成、上皮向间质转化、干细胞促进、免疫抑制和耐药，其活性与肿瘤生长和转移密切相关。FAP通过与β-整合素结合，协同促进肿瘤细胞的增殖、迁移和侵袭，其促血管生成特性归因于它的二肽基肽酶活性，其作用底物神经肽Y在裂解后能促血管生成和促进内皮细胞迁移。FAP的下游信号通路主要包括PI3K/AKT、RAS/ERK、SHH/GLI、FAK等。

热销产品

Recombinant Human Prolyl endopeptidase FAP (FAP), partial (CSB-EP008424HUa0)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

FAP Antibody (CSB-PA614259ESR2HU)

验证数据

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA614259ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA614259ESR2HU at dilution of 1:100

FAP Antibody

FAP Protein

FAP ELISA Kit

FAP Antibodies

FAP for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA614259ESR2HU	FAP Antibody	Human	ELISA, IHC
CSB-PA101830	FAP Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA008191	FAP Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA949422	FAP Antibody	Human,Mouse	ELISA,IHC
CSB-PA699536	FAP Antibody	Human,Mouse	ELISA,IHC

FAP Proteins

FAP Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP008424HU CSB-BP008424HU CSB-MP008424HU CSB-EP008424HU-B	Recombinant Human Prolyl endopeptidase FAP (FAP), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP008424HU	Recombinant Human Prolyl endopeptidase FAP (FAP), partial	E.coli
CSB-EP008424HUa0	Recombinant Human Prolyl endopeptidase FAP (FAP), partial	E.coli