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METAP2

METAP2,即甲硫氨酰氨肽酶2,别名MAP2、MNPEP、p67、Peptidase M等。它是一种在所有生物体中存在的酶,具有关键的组织修复和蛋白质降解功能。METAP2的作用机制主要是在蛋白质合成过程中,共翻译地移除新生多肽链上的N-末端甲硫氨酸,这一过程对于蛋白质的成熟和功能发挥至关重要。特别是,当多肽链的第二个残基是小的非极性氨基酸时,如丙氨酸、半胱氨酸、甘氨酸、脯氨酸、丝氨酸、苏氨酸或缬氨酸,METAP2的催化活性会显著提高 。METAP2在生物学上的意义非常广泛,它不仅参与了蛋白质合成的调控,还与多种生物学过程相关,包括血管生成、细胞增殖和肿瘤发展等。由于在血管生成中的关键作用,METAP2成为了治疗某些疾病如实体瘤癌症和类风湿性关节炎的潜在靶点。此外,METAP2的抑制剂,例如Fumagillin和Ovalicin,已被研究用于抗癌药物的开发,并且有研究显示,针对METAP2的抑制剂还能够有效治疗肥胖症 。

热销产品

Recombinant Human Methionine aminopeptidase 2 (METAP2) (CSB-EP013716HU)

验证数据

CSB-EP013716HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP013716HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013716HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) METAP2.

CSB-EP013716HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP013716HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) METAP2.

METAP2 Recombinant Monoclonal Antibody (CSB-RA294332A0HU)

验证数据

CSB-RA294332A0HU

IHC image of CSB-RA294332A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

METAP2 Antibodies

METAP2 for Homo sapiens (Human)

METAP2 Proteins

METAP2 Proteins for Homo sapiens (Human)