Osmr
OSMR，即抑瘤素M受体β链，别名白细胞介素31受体亚基β、Oncostatin-M特异性受体亚基β（isoform 2）、白细胞介素31受体亚基β、OSMR变异体1、Oncostatin-M特异性受体亚基β（isoform 1）、OSMRB、Oncostatin-M特异性受体β亚单位等。它是一种细胞表面受体，属于IL-6信号通路的成员，由人体细胞自身的基因编码。OSMR的作用机制主要是通过与Oncostatin M (OSM) 结合，激活其下游信号传导。OSMR与OSM的结合可以激活JAK/STAT、MAPK和PI3K等信号通路，进而调控细胞的增殖、分化和存活。OSMR在生物学上的意义主要体现在其参与调节多种生理和病理过程，包括细胞因子的产生、免疫反应、细胞增殖与凋亡等。OSMR的激活可以促进成纤维细胞、平滑肌细胞和卡波西肉瘤细胞的增殖，但对一些正常和肿瘤细胞系的生长则具有抑制作用。此外，OSMR还参与调节心脏肥大、纤维化重塑和心脏功能障碍的过程，其信号传导的异常激活与慢性炎症和心血管疾病的发展有关。因此，OSMR不仅在维持组织稳态和免疫平衡中发挥重要作用，也是药物开发中的潜在靶点，尤其在治疗肿瘤、关节炎和心血管疾病方面具有应用前景。
热销产品
Recombinant Human Oncostatin-M-specific receptor subunit beta (OSMR), partial (CSB-EP857869HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
OSMR Antibody (CSB-PA857869LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA857869LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA857869LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Osmr Antibodies
Osmr for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA857869LA01HU | OSMR Antibody | Human | ELISA, IHC, IF |
| CSB-PA857869LB01HU | OSMR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA857869LC01HU | OSMR Antibody, FITC conjugated | Human | |
| CSB-PA857869LD01HU | OSMR Antibody, Biotin conjugated | Human | ELISA |
Osmr Proteins
Osmr Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017261MO CSB-EP017261MO CSB-BP017261MO CSB-MP017261MO CSB-EP017261MO-B |
Recombinant Mouse Oncostatin-M-specific receptor subunit beta (Osmr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Osmr Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP727580RA CSB-EP727580RA CSB-BP727580RA CSB-MP727580RA CSB-EP727580RA-B |
Recombinant Rat Oncostatin-M-specific receptor subunit beta (Osmr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Osmr Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP857869HU CSB-BP857869HU CSB-MP857869HU CSB-EP857869HU-B |
Recombinant Human Oncostatin-M-specific receptor subunit beta (OSMR), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP857869HU | Recombinant Human Oncostatin-M-specific receptor subunit beta (OSMR), partial | E.coli |
