PDIA3

PDIA3，即蛋白质二硫键异构酶A3（Protein disulfide-isomerase A3），别名58 kDa glucose-regulated protein、58 kDa microsomal protein (p58)、Disulfide isomerase ER-60。它属于蛋白质二硫键异构酶(PDI)家族的成员，是一种在内质网中催化二硫键形成的酶，对蛋白质折叠和质量控制起着至关重要的作用。PDIA3作为分子伴侣，参与蛋白质的正确折叠、组装和分泌，尤其在细胞应激反应中高度表达，能够拦截与内质网应激相关的凋亡性细胞死亡。PDIA3在生物学上的意义非常广泛，其表达在约70%的癌症中升高，并且与肿瘤细胞的低侵袭性、存活和转移能力有关。PDIA3还与免疫激活标志物、癌症免疫细胞浸润和免疫调节剂显著相关，特别是能够显著预测抗PDL1治疗反应。此外，PDIA3在T细胞受体(TCR)信号通路中具有调控作用，能够促进T细胞的活化，参与调节T细胞TCR信号通路，影响ZAP70蛋白的磷酸化水平、CD69表达和IL-2的分泌，以及NF-κB信号通路。因此，PDIA3不仅在蛋白质合成、降解和分泌中发挥作用，塑造肿瘤微环境，还是癌症预后和免疫治疗反应的有力生物标志物，具有作为抗癌治疗靶点的潜力。

热销产品

Recombinant Human Protein disulfide-isomerase A3 (PDIA3) (CSB-EP017720HU)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PDIA3 Antibody (CSB-PA005150)

验证数据

Western Blot analysis of A549 HT29 K562 cells using ERp57 Polyclonal Antibody

Human protein disulfide-isomerase A3,PDIA3 ELISA Kit (CSB-E09798h)

验证数据

货号：CSB-E09798h

规格：96T/48T

灵敏度：0.31 ng/mL

检测范围：1.25 ng/mL-80 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

PDIA3 Antibody

PDIA3 Protein

PDIA3 ELISA Kit

PDIA3 Antibodies

PDIA3 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA06284A0Rb	PDIA3 Antibody	Human	ELISA
CSB-PA017720GA01HU	PDIA3 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA005150	PDIA3 Antibody	Human,Mouse,Rat	WB, ELISA

PDIA3 Proteins

PDIA3 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP017720RA CSB-EP017720RA CSB-BP017720RA CSB-MP017720RA CSB-EP017720RA-B	Recombinant Rat Protein disulfide-isomerase A3 (Pdia3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP017720MO CSB-EP017720MO CSB-BP017720MO CSB-MP017720MO CSB-EP017720MO-B	Recombinant Mouse Protein disulfide-isomerase A3 (Pdia3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP017720HU CSB-BP017720HU CSB-MP017720HU CSB-EP017720HU-B	Recombinant Human Protein disulfide-isomerase A3 (PDIA3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP017720HU	Recombinant Human Protein disulfide-isomerase A3 (PDIA3)	E.coli

PDIA3 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP017720BO CSB-EP017720BO CSB-BP017720BO CSB-MP017720BO CSB-EP017720BO-B	Recombinant Bovine Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Papio hamadryas (Hamadryas baboon)

产品货号	产品名称	来源
CSB-YP017720ERJ CSB-EP017720ERJ CSB-BP017720ERJ CSB-MP017720ERJ CSB-EP017720ERJ-B	Recombinant Papio hamadryas Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Mesocricetus auratus (Golden hamster)

产品货号	产品名称	来源
CSB-YP017720MRG CSB-EP017720MRG CSB-BP017720MRG CSB-MP017720MRG CSB-EP017720MRG-B	Recombinant Mesocricetus auratus Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

产品货号	产品名称	来源
CSB-YP684159DSU CSB-EP684159DSU CSB-BP684159DSU CSB-MP684159DSU CSB-EP684159DSU-B	Recombinant Chlorocebus aethiops Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Pongo abelii (Sumatran orangutan)

产品货号	产品名称	来源
CSB-YP712990PYX CSB-EP712990PYX CSB-BP712990PYX CSB-MP712990PYX CSB-EP712990PYX-B	Recombinant Pongo abelii Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDIA3 Proteins for Gallus gallus (Chicken)

产品货号	产品名称	来源
CSB-YP810332CH CSB-EP810332CH CSB-BP810332CH CSB-MP810332CH CSB-EP810332CH-B	Recombinant Chicken Protein disulfide-isomerase A3 (PDIA3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli