Ptk7

PTK7，即蛋白酪氨酸激酶7，别名CCK4（结肠癌激酶4）。它是一种跨膜受体蛋白，含有7个胞外Ig结构域、1个跨膜区、1个近膜区和1个催化惰性的细胞质酪氨酸激酶结构域。PTK7在脊椎动物的发育和胚胎生成中起着重要作用，特别是在平面细胞极化(PCP)和定向细胞运动的调节中。尽管PTK7缺乏酪氨酸激酶活性，但它能够与多种蛋白质相互作用，参与Wnt和非Wnt信号通路的调节，影响细胞的极性、运动、迁移和侵袭、组织再生和伤口愈合等过程。PTK7的作用机制涉及到其在Wnt/PCP信号通路和经典Wnt通路中的调节功能。在非典型Wnt通路中，PTK7能够与Frizzled受体和Dsh相互作用，参与信号的转导，激活GTP酶RhoA和Rac及其下游效应分子。在经典Wnt通路中，PTK7通过稳定细胞膜上的β-catenin发挥作用，促进LEF/TCF转录因子激活靶基因的表达。此外，PTK7还能够与VEGFR1相互作用，参与血管生成过程。PTK7的生物学意义主要体现在其对肿瘤发生、发展和转移的调控作用，其异常表达与多种肿瘤的发生和转移有关，尤其是在三阴性乳腺癌、非小细胞肺癌和卵巢癌中的表达量增加，与患者预后差有关。

热销产品

Recombinant Human Inactive tyrosine-protein kinase 7(PTK7),partial (Active) (CSB-MP622651HU2)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PTK7 at 2 μg/ml can bind Anti-PTK7 recombinant antibody (CSB-RA622651MA1HU). The EC₅₀ is 0.3675 - 0.65842 ng/mL.

The purity of PTK7 was greater than 95% as determined by SEC-HPLC

Recombinant Macaca fascicularis Protein tyrosine kinase 7 (inactive)(PTK7),Partial (Active) (CSB-MP5478MOV)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis PTK7 at 2 μg/ml can bind Anti-PTK7 recombinant antibody (CSB-RA622651MA1HU). The EC₅₀ is 1.399 - 1.666 ng/mL.

Ptk7 Antibody

Ptk7 Protein

Ptk7 ELISA Kit

Ptk7 Antibodies

Ptk7 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA018996LA01HU	PTK7 Antibody	Human	ELISA, IHC
CSB-PA018996LC01HU	PTK7 Antibody, FITC conjugated	Human
CSB-PA018996LD01HU	PTK7 Antibody, Biotin conjugated	Human	ELISA

Ptk7 Proteins

Ptk7 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP622651HU	Recombinant Human Inactive tyrosine-protein kinase 7 (PTK7), partial	Yeast
CSB-EP622651HU CSB-BP622651HU CSB-MP622651HU CSB-EP622651HU-B	Recombinant Human Inactive tyrosine-protein kinase 7 (PTK7), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP622651HU2	Recombinant Human Inactive tyrosine-protein kinase 7(PTK7),partial (Active)	Mammalian cell

Ptk7 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP804364MO	Recombinant Mouse Inactive tyrosine-protein kinase 7 (Ptk7), partial	Yeast
CSB-EP804364MO CSB-BP804364MO CSB-MP804364MO CSB-EP804364MO-B	Recombinant Mouse Inactive tyrosine-protein kinase 7 (Ptk7), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Ptk7 Proteins for Gallus gallus (Chicken)

产品货号	产品名称	来源
CSB-YP835490CH CSB-EP835490CH CSB-BP835490CH CSB-MP835490CH CSB-EP835490CH-B	Recombinant Chicken Inactive tyrosine-protein kinase 7 (PTK7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli