Slc6a4
SLC6A4，即钠依赖性神经递质转运蛋白，别名5-羟色胺转运体（5-HTT）、SERT等。SLC6A4是一种负责大脑中5-羟色胺（血清素）再摄取的跨膜蛋白，由人体细胞自身的基因编码。它的作用机制主要是通过钠离子和氯离子的共运输，将5-羟色胺从突触间隙中移回神经元，终止其信号传导作用，从而调节情绪、睡眠、食欲等生理过程。SLC6A4的信号通路涉及到5-羟色胺能神经系统，其活性受到多种因素的调控，包括细胞内外的离子浓度、神经递质浓度以及药物作用等。SLC6A4在生物学上的意义非常广泛，它不仅参与了情绪调节和认知功能，还与多种精神疾病的发生发展密切相关，如抑郁症、焦虑症、强迫症等。SLC6A4基因的多态性与个体对抑郁情绪的易感性有关，且抗抑郁药物的作用机制之一就是通过增加突触间隙中的5-羟色胺浓度来实现。此外，SLC6A4的功能异常还可能与某些神经退行性疾病相关。因此，SLC6A4是精神药理学研究和精神疾病治疗中的一个重要靶点。
热销产品
SLC6A4 Recombinant Monoclonal Antibody (CSB-RA224413A0HU)
验证数据
Western Blot
Positive WB detected in: U-87 whole cell lysate, 293T whole cell lysate, U-251 whole cell lysate, HepG2 whole cell lysate
All lanes: Serotonin transporter antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 71, 75 kDa
Observed band size: 55 kDa
IHC image of CSB-RA224413A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Slc6a4 Antibodies
Slc6a4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA550133 | SLC6A4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA363564 | SLC6A4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA224413A0HU | SLC6A4 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
Slc6a4 Proteins
Slc6a4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP021702HU CSB-EP021702HU CSB-BP021702HU CSB-MP021702HU CSB-EP021702HU-B |
Recombinant Human Sodium-dependent serotonin transporter (SLC6A4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
