Tcf3
TCF3，即转录因子3，别名E2A免疫球蛋白增强子结合蛋白、B-cell-specific transcription factor 3 (Bcl-3) 等。TCF3是一种基本螺旋-环-螺旋 (bHLH) 结构域的转录因子，属于T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) 家族成员。它在多种细胞类型中都有表达，并且在细胞增殖、分化、迁移和凋亡等过程中发挥重要作用。TCF3的作用机制涉及到与多种蛋白质和DNA序列的相互作用，能够调控下游基因的表达。TCF3在生物学上的意义非常广泛，它不仅参与了细胞的正常生理过程，还与多种疾病的发生发展密切相关。TCF3作为Wnt/β-catenin信号通路的主要效应分子，通过与β-catenin相互作用调控靶基因的转录。在肿瘤细胞中，TCF3的表达水平和活性与肿瘤的侵袭性、转移和耐药性有关，使其成为癌症治疗的潜在靶点。此外，TCF3还在干细胞的维持和分化中发挥作用，影响组织再生和发育。因此，对TCF3的研究不仅有助于我们理解其在正常生理过程中的作用，也为疾病的诊断和治疗提供了新的视角。
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验证数据
Western blot analysis of extracts from 293 cells, using TCF3 antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using TCF3 antibody.
Tcf3 Antibodies
Tcf3 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA023301GA01HU | TCF3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA123008 | Phospho-TCF3 (Thr355) Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA079787 | TCF3 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA004248 | TCF3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA050218 | Phospho-TCF3 (T355) Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA050219 | TCF3 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA023301HA01HU | TCF3 Antibody | Human | ELISA, IHC |
| CSB-PA023301HB01HU | TCF3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023301HD01HU | TCF3 Antibody, Biotin conjugated | Human | ELISA |
Tcf3 Proteins
Tcf3 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023301HU CSB-EP023301HU CSB-BP023301HU CSB-MP023301HU CSB-EP023301HU-B |
Recombinant Human Transcription factor E2-alpha (TCF3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Tcf3 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023301RA CSB-EP023301RA CSB-BP023301RA CSB-MP023301RA CSB-EP023301RA-B |
Recombinant Rat Transcription factor E2-alpha (Tcf3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Tcf3 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023301MO CSB-EP023301MO CSB-BP023301MO CSB-MP023301MO CSB-EP023301MO-B |
Recombinant Mouse Transcription factor E2-alpha (Tcf3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Tcf3 Proteins for Mesocricetus auratus (Golden hamster)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023301MRG CSB-EP023301MRG CSB-BP023301MRG CSB-MP023301MRG CSB-EP023301MRG-B |
Recombinant Mesocricetus auratus Transcription factor E2-alpha (TCF3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
