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npc2

Epididymal secretory protein E1 is a protein in humans that is encoded by NPC2 gene. Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1.

npc2 Antibodies

npc2 for Homo sapiens (Human)

npc2 for Dog

npc2 Proteins

npc2 Proteins for Bos taurus (Bovine)

npc2 Proteins for Homo sapiens (Human)

npc2 Proteins for Sus scrofa (Pig)

npc2 Proteins for Pan troglodytes (Chimpanzee)

npc2 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

npc2 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)

npc2 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)

npc2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

npc2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

npc2 Proteins for Ustilago maydis (strain 521 / FGSC 9021) (Smut fungus)

npc2 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

npc2 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

npc2 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

npc2 Proteins for Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)

npc2 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)

npc2 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

npc2 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

npc2 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)

npc2 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

npc2 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

npc2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

npc2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)