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ANO2 Antibody

  • 中文名称：
    ANO2兔多克隆抗体
  • 货号：
    CSB-PA001813GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NQ90
  • 基因名：
    ANO2
  • 别名：
    Ano2 antibody; ANO2_HUMAN antibody; Anoctamin 2 antibody; Anoctamin-2 antibody; C12orf3 antibody; Chromosome 12 open reading frame 3 antibody; DKFZp434P102 antibody; Transmembrane protein 16B (eight membrane-spanning domains) antibody; Transmembrane protein 16B antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human ANO2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
  • 基因功能参考文献：
    1. residues facing the putative channel pore are responsible both for controlling the ion selectivity and the gating of the channel, providing an initial understanding of molecular mechanism of ion permeation in TMEM16B PMID: 28046119
    2. data revealed prominently increased autoantibody reactivity against the chloride-channel protein anoctamin 2 (ANO2) in multiple sclerosis cases compared with controls PMID: 26862169
    3. Olfactory function impairment in Italian patients with type 3 von Willebrand disease with partial deletion of TMEM16B. PMID: 25635880
    4. ANO2 is present in human myometrium. PMID: 24928056
    5. The third intracellular loop of TMEM16B is the site involved in calcium ion sensitivity, whereas the C-terminal part affects the rate of transition between the open and the closed state of the channel. PMID: 23570556
    6. VWF and TMEM16B deletions may have a role in severe von Willebrand disease type 3 PMID: 17371490
    7. This study suggested that TMEM16B to be a strong candidate for the long sought-after Ca(2+)-dependent chloride channel in the photoreceptor synapse. PMID: 19474308
    8. Ano2 likely amplifies the odor-induced generator potential in olfactory sensory neuron cilia by sensing elevated calcium levels, permitting the outward flow of chloride ions from the cell. PMID: 19561302
    9. C12orf3, FLJ10261 (ORAOV2), C11orf25 and FLJ34272 constitute a family of eight-transmembrane proteins with N- and C-terminal tails facing the cytoplasm. PMID: 12739008

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Anoctamin family
  • 组织特异性：
    Retina, especially in the photoreceptor synaptic terminals.
  • 数据库链接：

    HGNC: 1183

    OMIM: 610109

    KEGG: hsa:57101

    STRING: 9606.ENSP00000314048

    UniGene: Hs.148970