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  4. ARCA Antibody

ARCA Antibody

  • 中文名称：
    ARCA兔多克隆抗体
  • 货号：
    CSB-PA359331XA01ENV
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: ARCA antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 31.4 kDa
      Observed band size: 33 kDa
  • 其他：

产品详情

  • Uniprot No.：
    P0A9Q1
  • 基因名：
    ARCA
  • 别名：
    Aerobic respiration control protein ArcA (Dye resistance protein) arcA cpxC dye fexA msp seg sfrA b4401 JW4364
  • 反应种属：
    Shigella flexneri
  • 免疫原：
    Recombinant Escherichia coli (strain K12) ARCA protein
  • 免疫原种属：
    Escherichia coli (strain K12)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Protein G
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. Controls the resistance of E.coli to dyes; required for expression of the alkaline phosphatase and sex factor F genes; It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expression of genes of aerobic function. Activates the transcription of the plfB operon by binding to its promoter.
  • 基因功能参考文献：
    1. The combined results indicate that ArcA controls metabolism, chemotaxis, and motility contributing to the pathogenicity of Avian pathogenic Escherichia coli PMID: 26099584
    2. We propose that this plasticity in ArcA binding site architecture provides both an efficient means of encoding binding sites for ArcA, sigma(70)-RNAP and perhaps other transcription factors PMID: 24146625
    3. The deletion of arcA results in a decrease of repression on transcription of tricarboxylic acid cycle genes under glucose abundant conditions, without significantly affecting the glyoxylate pathway activity. PMID: 21481254
    4. the activity of the regulator ArcA correlated with aerobiosis but not with the redox state of the ubiquinone pool, challenging the idea that ArcA activity is inhibited by oxidized ubiquinone. PMID: 21252224
    5. fadH promoter is regulated by three independent regulators, the fatty acid degradation FadR repressor, the oxygen-responsive ArcA-ArcB two-component system, and the cyclic AMP receptor protein-cyclic AMP. PMID: 20622065
    6. The ArcBA two-component system of Escherichia coli is regulated by the redox state of both the ubiquinone and the menaquinone pool. PMID: 19933363
    7. Knockout of ArcA-dependent redox regulation, however, increased the aerobic tricarboxylic acid (TCA) cycle activity by over 60%. PMID: 15838044
    8. ArcB/ArcA/RssB system is involved in sigmaS induction during entry into starvation conditions. PMID: 16291649
    9. must be regulatory factors other than ArcB interacting with ArcA to control flagella genes PMID: 17213678
    10. Activation of ArcA facilitates pIV-dependent induction of psp expression. PMID: 19682256
    11. These data show that the acetyl phosphate dependent ArcA phosphorylation route does not seem to play a significant role under physiological conditions. PMID: 19851741

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  • 亚细胞定位：
    Cytoplasm.
  • 数据库链接：

    KEGG: ecj:JW4364

    STRING: 316385.ECDH10B_4559