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GCNT2 Antibody

  • 中文名称：
    GCNT2兔多克隆抗体
  • 货号：
    CSB-PA844048ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: GCNT2 antibody at 3.99µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Mouse placenta tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 46, 47 kDa
      Observed band size: 46 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA844048ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA844048ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) GCNT2 Polyclonal antibody
  • Uniprot No.：
    Q8N0V5
  • 基因名：
    GCNT2
  • 别名：
    GCNT2 antibody; GCNT5 antibody; II antibody; NACGT1 antibody; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase antibody; N-acetylglucosaminyltransferase antibody; EC 2.4.1.150 antibody; I-branching enzyme antibody; IGNT antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase protein (203-402AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells.; Determines the expression of the blood group I antigen in erythrocytes.
  • 基因功能参考文献：
    1. miR-199a/b-5p regulates GCNT2 and I antigen expression in colon cancer cells undergoing EMT PMID: 28542779
    2. This study reports a novel insertion/deletion mutation at the GCNT2 locus that is responsible for congenital cataracts in a large consanguineous family. PMID: 27936067
    3. GCNT2 expression is closely associated with invasive potential of prostate cancer. PMID: 26678556
    4. Hypomethylation of the GCNT2 variant 2 reflected lymph node metastasis of colorectal cancer in the tumor and normal tissues. PMID: 25750292
    5. An Alu repeat-mediated genomic GCNT2 deletion underlies congenital cataracts and adult i blood group PMID: 21761136
    6. Results show involvement of GCNT2 in EMT and TGF-beta signaling, and further glycosylation modification of E-cadherin by GCNT2, are the underlying integrative mechanisms for breast cancer metastasis. PMID: 21750175
    7. In the family with the "ii" blood group a novel GCNT2 mutation was found in the cataract patients. PMID: 21541272
    8. The I carbohydrate antigen interacts simultaneously with the entire hydrophobic patch in framework region 1 and with the outside surface of Ig heavy chain complementarity-determining region 3, leaving most of the site available for binding other antigens. PMID: 12244172
    9. A nonsense mutation in the GCNT2 gene isoforms is associated with autosomal recessive congenital cataract in four distantly related Arab families from Israel. PMID: 15161861
    10. role of C/EBPalpha in the induction of the IGnTC gene as well as in I antigen expression PMID: 17855628

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  • 相关疾病：
    Cataract 13, with adult i phenotype (CTRCT13)
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 14 family
  • 组织特异性：
    [Isoform B]: Expressed in lens epithelium cells.; [Isoform C]: Expressed in reticulocytes.
  • 数据库链接：

    HGNC: 4204

    OMIM: 110800

    KEGG: hsa:2651

    STRING: 9606.ENSP00000265012

    UniGene: Hs.519884