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MRM2 Antibody

  • 中文名称：
    MRM2兔多克隆抗体
  • 货号：
    CSB-PA883420LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA883420LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) MRM2 Polyclonal antibody
  • Uniprot No.：
    Q9UI43
  • 基因名：
    MRM2
  • 别名：
    FJH1 antibody; FTSJ2 antibody; MRM2 antibody; Protein ftsJ homolog 2 antibody; Putative ribosomal RNA methyltransferase 2 antibody; Ribosomal RNA methyltransferase 2 antibody; RRMJ2_HUMAN antibody; rRNA (uridine-2''-O-)-methyltransferase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human rRNA methyltransferase 2, mitochondrial protein (19-246AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，MRM2 Antibody (CSB-PA883420LA01HU)，的标记方式是Non-conjugated。对于MRM2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA883420LB01HU MRM2 Antibody, HRP conjugated ELISA
    FITC CSB-PA883420LC01HU MRM2 Antibody, FITC conjugated
    Biotin CSB-PA883420LD01HU MRM2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
  • 基因功能参考文献：
    1. Targeted exome sequencing of genes encoding the mitochondrial proteome identified a damaging mutation, c.567 G > A, affecting a highly conserved amino acid residue (p.Gly189Arg) of the MRM2 protein. Our findings establish that defective MRM2 causes a MELAS-like phenotype, and suggests the genetic screening of the MRM2 gene in patients with a m.3243 A > G negative MELAS-like presentation. PMID: 28973171
    2. miR-542-3p functions as a suppressor gene by targeting and upregulating FTSJ2, thus inhibiting the malignancy of non-small cell lung cancer cells PMID: 28866101
    3. MRM2 and MRM3 are human mitochondrial methyltransferases involved in the modification of 16S rRNA and are important factors for the biogenesis and function of the large subunit of the mitochondrial ribosome. PMID: 25009282
    4. Data show that 2'-O-methyltransferases MRM1, MRM2, and RNMTL1 are responsible for modification of large subunit rRNA at residues G1145, U1369, and G1370, respectively. PMID: 25074936
    5. FTSJ2 possesses suppressive effects on the invasion and migration of cancer cells. PMID: 24595062
    6. FTSJ2 is a nucleolar RNA methyltransferase involved in eukaryotic RNA processing and modification. PMID: 11827451

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, RNA methyltransferase RlmE family
  • 组织特异性：
    Widely expressed, with highest expression in muscle, placenta, and heart.
  • 数据库链接：

    HGNC: 16352

    OMIM: 606906

    KEGG: hsa:29960

    STRING: 9606.ENSP00000242257

    UniGene: Hs.279877