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  4. Recombinant Human Putative ribosomal RNA methyltransferase 2 (FTSJ2)

Recombinant Human Putative ribosomal RNA methyltransferase 2 (FTSJ2)

  • 中文名称：
    人MRM2重组蛋白
  • 货号：
    CSB-YP883420HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MRM2重组蛋白
  • 货号：
    CSB-EP883420HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MRM2重组蛋白
  • 货号：
    CSB-EP883420HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MRM2重组蛋白
  • 货号：
    CSB-BP883420HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MRM2重组蛋白
  • 货号：
    CSB-MP883420HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MRM2
  • Uniprot No.：
  • 别名：
    FJH1; FTSJ2; MRM2; Protein ftsJ homolog 2; Putative ribosomal RNA methyltransferase 2; Ribosomal RNA methyltransferase 2; RRMJ2_HUMAN; rRNA (uridine-2''-O-)-methyltransferase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-246
  • 氨基酸序列
    MAGYLKLVCV SFQRQGFHTV GSRCKNRTGA EHLWLTRHLR DPFVKAAKVE SYRCRSAFKL LEVNERHQIL RPGLRVLDCG AAPGAWSQVA VQKVNAAGTD PSSPVGFVLG VDLLHIFPLE GATFLCPADV TDPRTSQRIL EVLPGRRADV ILSDMAPNAT GFRDLDHDRL ISLCLTLLSV TPDILQPGGT FLCKTWAGSQ SRRLQRRLTE EFQNVRIIKP EASRKESSEV YFLATQYHGR KGTVKQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
  • 基因功能参考文献：
    1. Targeted exome sequencing of genes encoding the mitochondrial proteome identified a damaging mutation, c.567 G > A, affecting a highly conserved amino acid residue (p.Gly189Arg) of the MRM2 protein. Our findings establish that defective MRM2 causes a MELAS-like phenotype, and suggests the genetic screening of the MRM2 gene in patients with a m.3243 A > G negative MELAS-like presentation. PMID: 28973171
    2. miR-542-3p functions as a suppressor gene by targeting and upregulating FTSJ2, thus inhibiting the malignancy of non-small cell lung cancer cells PMID: 28866101
    3. MRM2 and MRM3 are human mitochondrial methyltransferases involved in the modification of 16S rRNA and are important factors for the biogenesis and function of the large subunit of the mitochondrial ribosome. PMID: 25009282
    4. Data show that 2'-O-methyltransferases MRM1, MRM2, and RNMTL1 are responsible for modification of large subunit rRNA at residues G1145, U1369, and G1370, respectively. PMID: 25074936
    5. FTSJ2 possesses suppressive effects on the invasion and migration of cancer cells. PMID: 24595062
    6. FTSJ2 is a nucleolar RNA methyltransferase involved in eukaryotic RNA processing and modification. PMID: 11827451

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, RNA methyltransferase RlmE family
  • 组织特异性：
    Widely expressed, with highest expression in muscle, placenta, and heart.
  • 数据库链接：

    HGNC: 16352

    OMIM: 606906

    KEGG: hsa:29960

    STRING: 9606.ENSP00000242257

    UniGene: Hs.279877