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  4. Recombinant Bovine Carbonic anhydrase 2 (CA2)

Recombinant Bovine Carbonic anhydrase 2 (CA2)

  • 中文名称：
    Recombinant Bovine Carbonic anhydrase 2(CA2),Yeast
  • 货号：
    CSB-YP004370BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Bovine Carbonic anhydrase 2(CA2),Yeast
  • 货号：
    CSB-EP004370BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Bovine Carbonic anhydrase 2(CA2),Yeast
  • 货号：
    CSB-EP004370BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Bovine Carbonic anhydrase 2(CA2),Yeast
  • 货号：
    CSB-BP004370BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Bovine Carbonic anhydrase 2(CA2),Yeast
  • 货号：
    CSB-MP004370BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CA2
  • Uniprot No.：
  • 别名：
    CA2; Carbonic anhydrase 2; EC 4.2.1.1; Carbonate dehydratase II; Carbonic anhydrase II; CA-II
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-260
  • 氨基酸序列
    SHHWGYGKH NGPEHWHKDF PIANGERQSP VDIDTKAVVQ DPALKPLALV YGEATSRRMV NNGHSFNVEY DDSQDKAVLK DGPLTGTYRL VQFHFHWGSS DDQGSEHTVD RKKYAAELHL VHWNTKYGDF GTAAQQPDGL AVVGVFLKVG DANPALQKVL DALDSIKTKG KSTDFPNFDP GSLLPNVLDY WTYPGSLTTP PLLESVTWIV LKEPISVSSQ QMLKFRTLNF NAEGEPELLM LANWRPAQPL KNRQVRGFPK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide.
  • 基因功能参考文献：
    1. This study provides the first evidence that extra-platelet nitrite and erythrocytic CAII may modulate platelet function in a cGMP-dependent manner. PMID: 27129464
    2. binding of dorzolamide to bovine and human carbonic anhydrase II PMID: 26093313
    3. Increasing the number and distribution of surface acidic groups of CAII is sufficient to function in high-salt environments. PMID: 26687908
    4. Folding analysis of the zinc protein, carbonic anhydrase 2 was performed using electrospray ionization ion mobility spectrometry coupled with collision-induced dissociation. PMID: 20954754
    5. Intense positive staining for CA-II was found in luminal duct cells and for the first time also inside the duct lumen, clearly demonstrating the expression and secretion of salivary CA-II in bovine parotid glands. PMID: 20054804
    6. structure refined to 1.95 A resolution; has a C-terminal knot structure; contains one zinc ion in the active site coordinated to 3 his and 1 water molecule; structure reveals a probable alternative proton-wire pathway that differs from that of HCA II. PMID: 15039588
    7. novel series of mono- and bis- benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II PMID: 16213706
    8. catalytic activity of CAII affects the SNAT3 conductance, but presumably not by increasing the local H+ buffer capacity PMID: 17664347
    9. kinetics of refolding of carbonic anhydrase II following transfer from a buffer containing 5 m guanidinium chloride to a buffer containing 0.5 m guanidinium chloride PMID: 17878163
    10. The urea-induced unfolding of bovine carbonic anhydrase II, BCA II, is characterized by a combination of high-resolution NMR, circular dichroism spectroscopy and small angle X-ray scattering. PMID: 18359304
    11. Carbonic anhydrase II (BCA II) when incubated in mildly denaturing conditions showed that the partially unfolded conformers assemble together and form ordered amyloid aggregates. PMID: 18395531

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Alpha-carbonic anhydrase family
  • 数据库链接：

    KEGG: bta:280740

    STRING: 9913.ENSBTAP00000023581

    UniGene: Bt.49731