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  4. Recombinant Chicken Sclerostin domain-containing protein 1 (SOSTDC1)

Recombinant Chicken Sclerostin domain-containing protein 1 (SOSTDC1)

  • 中文名称：
    鸡SOSTDC1重组蛋白
  • 货号：
    CSB-YP764958CH
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    鸡SOSTDC1重组蛋白
  • 货号：
    CSB-EP764958CH
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    鸡SOSTDC1重组蛋白
  • 货号：
    CSB-EP764958CH-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    鸡SOSTDC1重组蛋白
  • 货号：
    CSB-BP764958CH
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    鸡SOSTDC1重组蛋白
  • 货号：
    CSB-MP764958CH
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    SOSTDC1; WISE; Sclerostin domain-containing protein 1; Wnt-signaling modulator
  • 种属：
    Gallus gallus (Chicken)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-206
  • 氨基酸序列
    AFKNDATE ILYSHVVKPA PASPSSNSTL NQARNGGRHY AGTGSDRNNR VQVGCRELRS TKYISDGQCT SINPLKELVC AGECLPLPLL PNWIGGGYGT KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG SIRTYKITVV TACKCKRYTR QHNESSHNFE GTSQAKPVQH HKERKRASKS SKHSTS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Can activate or inhibit Wnt signaling in a context-dependent manner. Activates the canonical Wnt pathway whereby acts through Disheveled proteins and beta-catenin. Antagonises Wnt signaling through the canonical pathways presumably by blocking accessibility of certain WNTs to their receptors. Induces posterior neural markers via components of the canonical Wnt pathway.
  • 基因功能参考文献：
    1. Wise is expressed in regions where other signaling molecules such as Wnt, Bmp, and Shh are known to function in morphogenesis and differentiation. PMID: 17654720
    2. While secreted Wise either synergizes or inhibits the Wnt signals depending on the partner ligand, ER-retained Wise consistently blocks the Wnt pathway. ER-retained Wise reduces LRP6 on the cell surface, making cells less susceptible to the Wnt signal. PMID: 17765217
    3. Wise is able to function cell non-autonomously on neural crest cells and promote trigeminal ganglion formation. PMID: 18538759
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Sclerostin family
  • 数据库链接：

    KEGG: gga:378800

    STRING: 9031.ENSGALP00000017538

    UniGene: Gga.9261