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  4. Recombinant Human Cytochrome P450 26A1 (CYP26A1)

Recombinant Human Cytochrome P450 26A1 (CYP26A1)

  • 中文名称：
    Recombinant Human Cytochrome P450 26A1(CYP26A1),Yeast
  • 货号：
    CSB-YP006402HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Cytochrome P450 26A1(CYP26A1),Yeast
  • 货号：
    CSB-EP006402HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Cytochrome P450 26A1(CYP26A1),Yeast
  • 货号：
    CSB-EP006402HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Cytochrome P450 26A1(CYP26A1),Yeast
  • 货号：
    CSB-BP006402HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Cytochrome P450 26A1(CYP26A1),Yeast
  • 货号：
    CSB-MP006402HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CYP26A1
  • Uniprot No.：
  • 别名：
    CP26; CP26A_HUMAN; CYP26; CYP26A 1; cyp26a1; Cytochrome P450 26A1; Cytochrome P450 family 26 subfamily A polypeptide 1; Cytochrome P450 retinoic acid-inactivating 1; cytochrome P450; family 26; subfamily A; polypeptide 1; cytochrome P450; subfamily XXVIA; polypeptide 1; Cytochrome P450RAI; hP450RAI; OTTHUMP00000020102; OTTHUMP00000020103; P450; P450 retinoic acid inactivating 1; P450RAI; P450RAI1; Retinoic acid 4 hydroxylase; Retinoic acid 4-hydroxylase; Retinoic acid metabolizing cytochrome; Retinoic acid-metabolizing cytochrome
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-497
  • 氨基酸序列
    MGLPALLASA LCTFVLPLLL FLAAIKLWDL YCVSGRDRSC ALPLPPGTMG FPFFGETLQM VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGADNVRRI LLGEHRLVSV HWPASVRTIL GSGCLSNLHD SSHKQRKKVI MRAFSREALE CYVPVITEEV GSSLEQWLSC GERGLLVYPE VKRLMFRIAM RILLGCEPQL AGDGDSEQQL VEAFEEMTRN LFSLPIDVPF SGLYRGMKAR NLIHARIEQN IRAKICGLRA SEAGQGCKDA LQLLIEHSWE RGERLDMQAL KQSSTELLFG GHETTASAAT SLITYLGLYP HVLQKVREEL KSKGLLCKSN QDNKLDMEIL EQLKYIGCVI KETLRLNPPV PGGFRVALKT FELNGYQIPK GWNVIYSICD THDVAEIFTN KEEFNPDRFM LPHPEDASRF SFIPFGGGLR SCVGKEFAKI LLKIFTVELA RHCDWQLLNG PPTMKTSPTV YPVDNLPARF THFHGEI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers. May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid.
  • 基因功能参考文献：
    1. Accumulating evidence suggest that cytochrome P450 (CYP26), the primary retinoid-inactivating enzyme, plays a critical role in the integration of two neoplastic molecular programs: the retinoid metabolism and Hedgehog pathways. (Review) PMID: 28754309
    2. CYP26A1 polymorphisms were associated with increased risk of malignant oral disorders in betel quid chewers. PMID: 25839051
    3. CYP26A1-mediated oncogenic characteristics may be partially responsible for the elevated expression of fascin. PMID: 26058854
    4. Molecular recognition of CYP26A1 binding pockets and structure-activity relationship studies for design of potent and selective retinoic acid metabolism blocking agents has been described. PMID: 25541526
    5. data suggested that CYP26A1 overexpression might contribute to the development and progression of cervical malignancies and squamous neoplasia of the head and neck PMID: 25294402
    6. HNF4alpha coordinates with retinoic acid receptors in a retinoic acid-dependent manner to strongly induce CYP26A1 gene expression in the liver, which may explain the high level of response to retinoic acid observed in vivo. PMID: 24819304
    7. In liver microsomes, CYP26A1 plays a role in clearing bioactive retinoids. PMID: 25492813
    8. CYP26 is able to inactivate retinoids in serum, preventing retinoic acid signaling and thus bone-marrow hematopoietic stem cell differentiation. PMID: 24043786
    9. The promoter region of CYP26A1 is significantly hypermethylated in allergic asthmatic subjects. PMID: 21975512
    10. Our observation suggests an involvement of enhanced CYP26A1 expression causing a functional vitamin A deficieny state in skin that can potentially lead to neoplastic transformation of keratinocytes in an early phase during skin carcinogenesis PMID: 22179182
    11. CYP26A1 and CYP26B1 are qualitatively similar retinoic acid hydroxylases with overlapping expression profiles; CYP26A1 has higher catalytic activity than CYP26B1. PMID: 22020119
    12. CYP26A1 and CYP26C1 play a pivotal role in the pathogenesis of nonsyndromic bilateral and unilateral optic nerve aplasia. PMID: 21850183
    13. Primary metabolites of all-trans-retinoic acid formed by CYP26A1 are identified and the ligand selectivity and ligand interactions of CYP26A1 are characterized. PMID: 21521770
    14. the functioning of multiple RAREs may account for the strong inducibility of CYP26A1 in liver, which, in turn, may be important physiologically for restoring retinoid homeostasis when the concentration of RA rises. PMID: 20682464
    15. CYP26A1 is expressed in human liver microsomes; its expression correlates with retinoic acid hydroxylation. PMID: 20513361
    16. The identification of a functional retinoic acid response element located 2.0 kb upstream of the Cyp26A1 transcriptional start site is reported. PMID: 16053444
    17. induction and regulation of CYP26A1 expression in human intestinal (Caco-2), liver (HepG2), endothelial (HUVEC), and APL (NB4) cell lines PMID: 16194896
    18. Variants in CYP26A1 are unlikely to be a major risk factor for caudal regression syndrome; further study with a larger number of genotyped subjects is required. PMID: 16463413
    19. Constitutive expression of CYP26AI in vivo and in organotypic culture was found to be restricted to basal epidermal keratinocytes, as well as eccrine sweat glands and sebaceous glands. PMID: 16778795
    20. g.3116delT mutation is of particular interest because it was identified in a patient with spina bifida and likely encodes a truncated protein with no enzymatic activity, as demonstrated by preliminary in vitro data. PMID: 16933217
    21. analysis of CYP26A1 active site architecture and ligand binding PMID: 17059167
    22. Low CYP26A1 expression may explain high risk of resistance installation, by increase retinoid pressure. PMID: 17218384
    23. Three new alleles termed as CYP26A1*2, CYP26A1*3, and CYP26A1*4, are potentially defective in all-trans retinoic acid metabolism. PMID: 17460545
    24. Overexpression of CYP26A1 causes intracellular retinoic acid depletion and drives the cell into a highly proliferative and invasive state with induction of other known oncogenes PMID: 18059332
    25. Results provide a biochemical framework for CYP26A1 function and offer insight into the role of CYP26A1 as a drug target as well as in fetal development and cell cycle regulation PMID: 18992717
    26. cytochrome P450 family 26 (CYP26) enzymes have a role in determining the cellular exposure to retinoic acid by inactivating retinoic acid in cells that do not need retinoic acid--REVIEW PMID: 19519282

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Expressed in most fetal and adult tissues with highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain. Expressed at high levels in lung, pancreas, skin and uterus (at protein level). Lower expression level
  • 数据库链接：

    HGNC: 2603

    OMIM: 602239

    KEGG: hsa:1592

    STRING: 9606.ENSP00000224356

    UniGene: Hs.150595