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  4. Recombinant Human Protein HEXIM2 (HEXIM2)

Recombinant Human Protein HEXIM2 (HEXIM2)

  • 中文名称：
    人HEXIM2重组蛋白
  • 货号：
    CSB-YP846669HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HEXIM2重组蛋白
  • 货号：
    CSB-EP846669HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HEXIM2重组蛋白
  • 货号：
    CSB-EP846669HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HEXIM2重组蛋白
  • 货号：
    CSB-BP846669HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HEXIM2重组蛋白
  • 货号：
    CSB-MP846669HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HEXIM2
  • Uniprot No.：
  • 别名：
    Hexamethylene bis-acetamide-inducible protein 2; Hexamthylene bis-acetamide inducible 2 ; HEXI2_HUMAN; hexim 2; HEXIM2; L3; Protein HEXIM2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-286
  • 氨基酸序列
    MMATPNQTAC NAESPVALEE AKTSGAPGSP QTPPERHDSG GSLPLTPRME SHSEDEDLAG AVGGLGWNSR SPRTQSPGGC SAEAVLARKK HRRRPSKRKR HWRPYLELSW AEKQQRDERQ SQRASRVREE MFAKGQPVAP YNTTQFLMND RDPEEPNLDV PHGISHPGSS GESEAGDSDG RGRAHGEFQR KDFSETYERF HTESLQGRSK QELVRDYLEL EKRLSQAEEE TRRLQQLQAC TGQQSCRQVE ELAAEVQRLR TENQRLRQEN QMWNREGCRC DEEPGT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
  • 基因功能参考文献：
    1. HEXIM2 can functionally and quantitatively compensate for the loss of HEXIM1 PMID: 15713661
    2. utilization of HEXIM1 or HEXIM2 to bind and inhibit P-TEFb can be differentially regulated in vivo. PMID: 15713662
    3. Positive transcription elongation factor b regulates eukaryotic gene expression at the level of elongation and is controlled by the reversible association with HEXIM2. PMID: 15965233
    4. The tripartite protein-RNA complex formation between Hexim, Cyclin T and 7SK snRNA, was analyzed. PMID: 19883659
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HEXIM family
  • 组织特异性：
    Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed.
  • 数据库链接：

    HGNC: 28591

    OMIM: 615695

    KEGG: hsa:124790

    STRING: 9606.ENSP00000302276

    UniGene: Hs.56382