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  4. Recombinant Human Protein SOX-15 (SOX15)

Recombinant Human Protein SOX-15 (SOX15)

  • 中文名称：
    人SOX15重组蛋白
  • 货号：
    CSB-YP022423HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SOX15重组蛋白
  • 货号：
    CSB-EP022423HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SOX15重组蛋白
  • 货号：
    CSB-EP022423HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SOX15重组蛋白
  • 货号：
    CSB-BP022423HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SOX15重组蛋白
  • 货号：
    CSB-MP022423HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SOX15
  • Uniprot No.：
  • 别名：
    Protein SOX-12; Protein SOX-15; Protein SOX-20; SOX 12 protein ; SOX 15; SOX 15 protein; SOX 20 protein; SOX12; SOX12 protein ; SOX15; SOX15 protein; SOX15_HUMAN; SOX20; SOX20 protein; SOX26; SOX27; SRY box 15; SRY sex determining region Y box 15; SRY sex determining region Y box 20 ; SRYbox 15
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-233
  • 氨基酸序列
    MALPGSSQDQ AWSLEPPAAT AAASSSSGPQ EREGAGSPAA PGTLPLEKVK RPMNAFMVWS SAQRRQMAQQ NPKMHNSEIS KRLGAQWKLL DEDEKRPFVE EAKRLRARHL RDYPDYKYRP RRKAKSSGAG PSRCGQGRGN LASGGPLWGP GYATTQPSRG FGYRPPSYST AYLPGSYGSS HCKLEAPSPC SLPQSDPRLQ GELLPTYTHY LPPGSPTPYN PPLAGAPMPL THL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence. Acts as a transcriptional activator and repressor. Binds synergistically with POU5F1 (OCT3/4) to gene promoters. Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation. Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG. Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity. Regulates transcription of HRC via binding to it proximal enhancer region. Involved in skeletal muscle regeneration. Also plays a role in the development of myogenic precursor cells.
  • 基因功能参考文献：
    1. SOX15 can be a tumor suppressor in colorectal cancer by suppressing the Wnt-beta-catenin signaling pathway. PMID: 30019915
    2. SOX15 could regulate the proliferation and migration of endometrial cancer cells and up- regulation of SOX15 could be valuable for endometrial cancer treatment. PMID: 28821564
    3. Increased expression of epithelial OCT4, SOX15 and TWIST1 was detected in endometriotic tissue compared to endometriosis patient endometrium. Epithelial expression of OCT4, SOX15, and TWIST1 was increased in the endometrium of endometriosis patients compared to controls. PMID: 27881125
    4. Results indicate that the expression of SOX15 in pancreatic cancer cell lines with undetectable expression resulted in reduced viability of cancer cells both in vitro and in vivo demonstrating its tumor suppressive capability. PMID: 23318427
    5. We established stable NT2/D1 cell lines overexpressing SOX15 (SOX15-NT2/D1), and a modified 3-(4,5-dime-thylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that the SOX15-NT2/D1 cells exhibited significantly slower growth than controls PMID: 18182846
    6. The gain of function studies indicated that sex-determining region Y (SRY)-box 15 (SOX15) activate NR5A1 gene expression. PMID: 18579725

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.
  • 数据库链接：

    HGNC: 11196

    OMIM: 601297

    KEGG: hsa:6665

    STRING: 9606.ENSP00000355354

    UniGene: Hs.95582