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  4. Recombinant Human Ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1)

Recombinant Human Ubiquitin-like domain-containing CTD phosphatase 1 (UBLCP1)

  • 中文名称：
    人UBLCP1重组蛋白
  • 货号：
    CSB-YP851974HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人UBLCP1重组蛋白
  • 货号：
    CSB-EP851974HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人UBLCP1重组蛋白
  • 货号：
    CSB-EP851974HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人UBLCP1重组蛋白
  • 货号：
    CSB-BP851974HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人UBLCP1重组蛋白
  • 货号：
    CSB-MP851974HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    UBLCP1
  • Uniprot No.：
  • 别名：
    CPUB1; CTD like phosphatase domain containing protein; CTD phosphatase like with ubiquitin domain 1; FLJ25267; MGC10067; Nuclear proteasome inhibitor UBLCP1; UBCP1_HUMAN; Ubiquitin like domain containing CTD phosphatase 1; Ubiquitin-like domain-containing CTD phosphatase 1; UBLCP1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-318
  • 氨基酸序列
    ALPIIVKWG GQEYSVTTLS EDDTVLDLKQ FLKTLTGVLP ERQKLLGLKV KGKPAENDVK LGALKLKPNT KIMMMGTREE SLEDVLGPPP DNDDVVNDFD IEDEVVEVEN REENLLKISR RVKEYKVEIL NPPREGKKLL VLDVDYTLFD HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EFYSKKNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLTQY LKEIAKLDDF LDLNHKYWER YLSKKQGQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.
  • 基因功能参考文献：
    1. Data show that UBLCP1 selectively binds to the 26S proteasome non-ATPase regulatory subunit 13 (19S regulatory particle) in regulating proteasome assembly. PMID: 28539385
    2. the high-resolution solution structure of the UBL domain of human UBLCP1 and its interaction with Rpn1 PMID: 23667555
    3. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity PMID: 21949367
  • 亚细胞定位：
    Nucleus. Note=Colocalizes with nuclear proteasomes.
  • 组织特异性：
    Broadly expressed, with highest levels in placenta, lung, testis and ovary. Up-regulated in tumor tissues.
  • 数据库链接：

    HGNC: 28110

    OMIM: 609867

    KEGG: hsa:134510

    STRING: 9606.ENSP00000296786

    UniGene: Hs.591733