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  4. Recombinant Mouse Forkhead box protein H1 (Foxh1)

Recombinant Mouse Forkhead box protein H1 (Foxh1)

  • 中文名称：
    小鼠Foxh1重组蛋白
  • 货号：
    CSB-YP008817MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Foxh1重组蛋白
  • 货号：
    CSB-EP008817MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Foxh1重组蛋白
  • 货号：
    CSB-EP008817MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Foxh1重组蛋白
  • 货号：
    CSB-BP008817MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Foxh1重组蛋白
  • 货号：
    CSB-MP008817MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxh1
  • Uniprot No.：
  • 别名：
    Foxh1; Fast1; Fast2; Forkhead box protein H1; Forkhead activin signal transducer 1; Fast-1; Forkhead activin signal transducer 2; Fast-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-401
  • 氨基酸序列
    MASGWDLAST YTPTTPSPQL ALAPAQGYLP CMGPRDNSQL RPPEAESLSK TPKRRKKRYL RHDKPPYTYL AMIALVIQAA PFRRLKLAQI IRQVQAVFPF FRDDYEGWKD SIRHNLSSNR CFHKVPKDPA KPQAKGNFWA VDVSLIPAEA LRLQNTALCR RWQNRGTHRA FAKDLSPYVL HGQPYQPPSP PPPPREGFSI KSLLGDPGKE STWPQHPGLP GQSTAAQAGT LSKGEEGMGT GPSSSSETPL WPLCSLPGPT IIEGESSQGE VIRPSPVTPD QGSWPLHLLE DSADSRGVPR RGSRASLWGQ LPTSYLPIYT PNVVMPLATL PTTSCPQCPS SASPAYWSVG TESQGSQDLL CDLDSLFQGV PPNKSIYDVW VSHPRDLAAP APGWLLSWYS M
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).
  • 基因功能参考文献：
    1. that FAST2 is expressed in a cell-specific manner during ovarian follicle development PMID: 27432806
    2. The finding that Foxh1-Grg-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg interactions. PMID: 25511461
    3. Formation of midgut and hindgut definitive endoderm is unaffected by loss of Foxh1 or Foxa2. PMID: 19896480
    4. A conserved intronic enhancer (ASE), containing binding sites for the fork head transcription factor Foxh1, modulates dynamic patterns of Nodal expression during early mouse development. PMID: 12091315
    5. Foxh1 and Nkx2-5 functionally interact and are essential for development of the anterior heart field and its derivatives PMID: 15363409
    6. As goosecoid is itself induced in a Foxh1-dependent manner, we propose that Foxh1 initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation PMID: 17568773
    7. Foxh1 initiates a transcriptional regulatory network within the developing anterior neuroectoderm. PMID: 18331719

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:14106

    STRING: 10090.ENSMUSP00000036591

    UniGene: Mm.42011