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  4. Recombinant Mouse Homeobox protein Hox-A5 (Hoxa5)

Recombinant Mouse Homeobox protein Hox-A5 (Hoxa5)

  • 中文名称：
    小鼠Hoxa5重组蛋白
  • 货号：
    CSB-YP010655MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hoxa5重组蛋白
  • 货号：
    CSB-EP010655MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hoxa5重组蛋白
  • 货号：
    CSB-EP010655MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hoxa5重组蛋白
  • 货号：
    CSB-BP010655MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hoxa5重组蛋白
  • 货号：
    CSB-MP010655MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxa5
  • Uniprot No.：
  • 别名：
    Hoxa5; Hox-1.3; Hoxa-5; Homeobox protein Hox-A5; Homeobox protein Hox-1.3; Homeobox protein M2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-270
  • 氨基酸序列
    MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN GMDLSVGRSG SGHFGSGERA RSYAAGASAA PAEPRYSQPA TSTHSPPPDP LPCSAVAPSP GSDSHHGGKN SLGNSSGASA NAGSTHISSR EGVGTASAAE EDAPASSEQA GAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
  • 基因功能参考文献：
    1. study implicates HOXA5 as a chromosome 7-associated gene-level locus that promotes selection for gain of whole chromosome 7 and an aggressive phenotype in glioblastoma. PMID: 29632085
    2. Hoxa5 expression in the mesenchyme and phrenic motor neurons controls distinct aspects of respiratory development. PMID: 29074702
    3. Hoxa5 increased adipocytes differentiation and mitochondrial biogenesis in adipocytes in vitro. CEBPbeta was determined a transcription factor of Hoxa5 and inhibited methylation level of Hoxa5 by combining on the promoter of Hoxa5. PMID: 29439250
    4. Hoxa5 possesses tissue-specific functions that differentially contribute to the morphogenesis of the respiratory tract. PMID: 28827394
    5. mapping analysis allowed us to build hypotheses regarding HOXA5 functions in the nervous system after birth, such as a potential role in the establishment and refinement/plasticity of precerebellar circuits during postnatal and adult life PMID: 27650319
    6. Methylation profiling of HoxA5 gene promoter shows higher methylation in adult as compared to fetus in various somatic tissues of mouse being highest in adult spleen. However q-PCR results show higher expression during fetal stages being highest in fetal intestine followed by brain, liver and spleen. These results clearly indicate a strict correlation between DNA methylation and tissue-specific gene expression. PMID: 28363633
    7. In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis. PMID: 26678341
    8. HoxA5 represents a novel molecule for restricting pathological and tumorigenic angiogenesis. PMID: 25821967
    9. Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo. PMID: 25590986
    10. YY1 acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis. PMID: 24705708
    11. Hoxa5 and Hoxb5 paralog genes share some functions during lung morphogenesis; Hoxa5 plays a predominant role. PMID: 23585229
    12. Two Hox genes, Hoxa5 and Hoxc5, control diverse aspects of phrenic motor column development. PMID: 23103965
    13. Hoxa5, a stroma-specific gene, plays a significant role in ovarian biology and may be involved in ovarian cancer predisposition PMID: 22315454
    14. Hoxa5 larger transcripts may participate in the control of Hox gene expression. PMID: 20485555
    15. Hoxa5 and p53 cooperate in mammary tumorigenesis in vivo. PMID: 20042682
    16. involved in formation of pectoral girdle PMID: 11900462
    17. findings provide insight into the molecular controls of patterning events of the stomach, supporting the notion that Hoxa5 acts in regionalization and specification of the stomach by setting up the proper domains of expression of signaling molecules PMID: 12163410
    18. Hoxa5 has a role in thyroid morphology and transient hypothyroidism PMID: 12815622
    19. Using HOXA5-specific antibodies,show this expression pattern is ectopic as the endogenous protein is expressed only in the ventral spinal cord at this anterio-posterior level. And also displays forelimb-specific motor and sensory defects. PMID: 15158076
    20. When exposed to ventilatory stimuli, Hoxa5(-/-) mice maintain the higher minute ventilation by adapting the tidal volume and/or the breathing frequency. PMID: 15295088
    21. Increased DNA methylation contributes to the downregulation of HoxA5, which might facilitate the clonal expansion of increasingly aberrant cells during promotion. PMID: 15352125
    22. HOXA5 protein pattern is consistent with its proposed role in positional specification in mesodermal structures, as well as in the embryonic neuraxis. PMID: 15922675
    23. There is the essential contribution of Hoxa5 to mammary epithelium instruction by means of mesenchymal-epithelial crosstalk. PMID: 16607641
    24. Hoxa5 function has severe repercussions on postnatal lung development. PMID: 17003488
    25. Analysis of neighboring Hox gene expression patterns in the Hoxa5 mutants. PMID: 17417799
    26. Altered Hox protein temporal and cellular balance of expression either contributes to pulmonary hypoplasia or functions as a compensatory mechanism attempting to correct abnormal lung development and maturation in this condition. PMID: 18553509
    27. HoxA5 increases Akt1 mRNA, protein expression and further enhances Akt activity via a coordinate down regulation of PTEN. PMID: 19262140
    28. Restoration of HoxA5 was associated with increased thrombospondin-2, which inhibits angiogenesis and reduced hypoxia-inducible factor 1alpha expression PMID: 19458547

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    KEGG: mmu:15402

    STRING: 10090.ENSMUSP00000039012

    UniGene: Mm.173