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  4. Recombinant Mouse Homeobox protein Hox-A7 (Hoxa7)

Recombinant Mouse Homeobox protein Hox-A7 (Hoxa7)

  • 中文名称：
    小鼠Hoxa7重组蛋白
  • 货号：
    CSB-YP010657MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hoxa7重组蛋白
  • 货号：
    CSB-EP010657MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hoxa7重组蛋白
  • 货号：
    CSB-EP010657MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hoxa7重组蛋白
  • 货号：
    CSB-BP010657MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hoxa7重组蛋白
  • 货号：
    CSB-MP010657MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxa7
  • Uniprot No.：
  • 别名：
    Hoxa7; Hox-1.1; Hoxa-7; Homeobox protein Hox-A7; Homeobox protein Hox-1.1; Homeobox protein M6-12; M6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-229
  • 氨基酸序列
    MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GPGAGAFAST VPGLYNVNSP LYQSPFASGY GLGADAYNLP CASYDQNIPG LCSDLAKGAC DKADEGVLHG PAEASFRIYP WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF NRYLTRRRRI EIAHALCLTE RQIKIWFQNR RMKWKKEHKD ESQAPTAAPE DAVPSVSTAA DKADEEEEEE EEEEEEEEE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. the cohesin complex regulates PRC2 targeting to silence Hoxa7 and Hoxa9 and negatively regulate self-renewal. Our studies identify a novel epigenetic mechanism underlying leukemogenesis in AML patients with cohesin mutations. PMID: 27554164
    2. The retinoic acid response element in the regulatory region affects the rate, not the formation of anterior boundary expression PMID: 12068955
    3. Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1. PMID: 12082612
    4. novel dna binding protein of Hoxa7 promoter; sequence analysis revealed that protein C171 contained one hydrophobic transmembrane domain in the N-terminal region and several putative phosphorylation and glycosylation sites PMID: 12549822
    5. impact of Hoxa7 or Hoxa9 nullizygosity on hematopoietic progenitor compartments and their susceptibility to MLL-induced leukemias PMID: 15070702
    6. during development, Hox expression boundaries become set along instructional cdx gradients, formed by cdx decay in cells moving away from the primitive streak region PMID: 15470633

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    KEGG: mmu:15404

    STRING: 10090.ENSMUSP00000048648

    UniGene: Mm.294826