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  4. Recombinant Mouse LIM/homeobox protein Lhx8 (Lhx8)

Recombinant Mouse LIM/homeobox protein Lhx8 (Lhx8)

  • 中文名称：
    小鼠Lhx8重组蛋白
  • 货号：
    CSB-YP012925MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lhx8重组蛋白
  • 货号：
    CSB-EP012925MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lhx8重组蛋白
  • 货号：
    CSB-EP012925MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lhx8重组蛋白
  • 货号：
    CSB-BP012925MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lhx8重组蛋白
  • 货号：
    CSB-MP012925MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lhx8
  • Uniprot No.：
  • 别名：
    Lhx8; Lhx7LIM/homeobox protein Lhx8; LIM homeobox protein 8; L3; LIM/homeobox protein Lhx7; LIM homeobox protein 7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-367
  • 氨基酸序列
    MYWKSDQMFV CKLEGKEVPE LAVPREKCPG LMSEECGRPA ALAAGRTRKG AGEEGLVNPE GAGDEDSCSS SAPLSPSSSP QSMASGSVCP PGKCVCSSCG LEIVDKYLLK VNDLCWHVRC LSCSVCRTSL GRHTSCYIKD KDIFCKLDYF RRYGTRCSRC GRHIHSTDWV RRAKGNVYHL ACFACFSCKR QLSTGEEFAL VEEKVLCRVH FDCMLDNLKR EVENGNGISV EGALLTEQDV NHPKPAKRAR TSFTADQLQV MQAQFAQDNN PDAQTLQKLA ERTGLSRRVI QVWFQNCRAR HKKHVSPNHS SSAPVTAVPS SRLSPPMLEE MAYSAYVPQD GTMLTALHSY MDAHQQLLDS SPCYPIQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
  • 基因功能参考文献：
    1. LHX8 can bind to the Lin28a promoter, and the depletion of Lin28a in Lhx8-deficient oocytes partially suppresses primordial oocyte activation. PMID: 26076587
    2. WNT/beta-catenin signaling is essential for the expression of Lhx8 in the maxillary arch cells. PMID: 25190800
    3. Lhx8 expression is related with the activation of primordial follicles, which is highly correlated with the demethylation of Lhx8-3' untranslated region and the high acetylation of histone H3. PMID: 22796561
    4. The homeodomain protein LIM homeobox (Lhx)7 is essential for maintaining the morphological and molecular characteristics of cholinergic interneurons of the striatum. PMID: 22315402
    5. L3/Lhx8 functions may be partially redundant in the mesenchyme of the secondary palate, but not in the palatal epithelium. PMID: 12086327
    6. Lhx8 plays an important role in the survival of mesenchymal cells of the tooth germ during development. PMID: 12703558
    7. mice with a null mutation of Lhx8 are deficient in the development of forebrain cholinergic neurons PMID: 12855770
    8. Overall our experiments demonstrate that Lhx7 expression is required for the specification or differentiation of cholinergic forebrain neurons involved in the processing of spatial information. PMID: 15978004
    9. The reduction of forebrain choline acetyltransferase immunoreactive neurons in Lhx7 homozygous mutants is accompanied by a decrease of acetylcholinesterase histochemical staining in all forebrain cholinergic neurons. PMID: 16338089
    10. Sohlh1 and Lhx8 are two germ cell-specific, critical regulators of oogenesis PMID: 16690745
    11. Results strongly suggest that L3/Lhx8 is a key factor in the cholinergic differentiation of embryonic stem cells and is involved in basal forebrain development. PMID: 17318222
    12. These results strongly suggest that L3/Lhx8 is a key factor for cholinergic differentiation of murine ES cell-derived spheres and is involved in basal forebrain development. PMID: 18248940
    13. Lhx8 is a critical factor for maintenance and differentiation of the oocyte during early oogenesis, and it acts in part by downregulating the Nobox pathway. PMID: 18509161
    14. Data show that Lhx8 is regionally enriched in the Basal Nucleus of Meynert of mouse brain. PMID: 18625066
    15. LHX7 null mutants display a sex-dependent impairment in water maze; females more affected than males; findings show an increase of BDNF & neurotrophin 3 in neocortex of male & female mutants & an increase of nerve growth factor only in females PMID: 19095044

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:16875

    STRING: 10090.ENSMUSP00000136047

    UniGene: Mm.15530