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  4. Recombinant Mouse Matrilin-3 (Matn3)

Recombinant Mouse Matrilin-3 (Matn3)

  • 中文名称：
    小鼠Matn3重组蛋白
  • 货号：
    CSB-YP013522MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Matn3重组蛋白
  • 货号：
    CSB-EP013522MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Matn3重组蛋白
  • 货号：
    CSB-EP013522MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Matn3重组蛋白
  • 货号：
    CSB-BP013522MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Matn3重组蛋白
  • 货号：
    CSB-MP013522MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Matn3
  • Uniprot No.：
  • 别名：
    Matn3Matrilin-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-481
  • 氨基酸序列
    APG RLARASVRRL GTRVPGGSPG HLSALATSTR APYSGGRGAG VCKSRPLDLV FIIDSSRSVR PLEFTKVKTF VSRIIDTLDI GATDTRVAVV NYASTVKIEF QLNTYSDKQA LKQAVARITP LSTGTMSGLA IQTAMEEAFT VEAGARGPMS NIPKVAIIVT DGRPQDQVNE VAARARASGI ELYAVGVDRA DMESLKMMAS KPLEEHVFYV ETYGVIEKLS ARFQETFCAL DQCMLGTHQC QHVCVSDGDG KHHCECSQGY TLNADGKTCS AIDKCALSTH GCEQICVNDR NGSYHCECYG GYALNADRRT CAALDKCASG THGCQHICVN DGAGSHHCEC FEGYTLNADK KTCSVRNKCA LGTHGCQHIC VSDGAVAYHC DCFPGYTLND DKKTCSDIEE ARSLISIEDA CGCGATLAFQ EKVSSHLQKL NTKLDNILKK LKVTEYGQVH R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.
  • 基因功能参考文献：
    1. Data show that hand osteoarthritis (HOA)-related matrilin-3 mutation (T298M) leads to a high expression level of growth arrest DNA damage-inducible gene 153 (GADD153) PMID: 26499313
    2. MATN3 plays a regulatory role in cartilage homeostasis due to its capacity to induce IL-1Ra, upregulate gene expression of major cartilage matrix components, and downregulate the expression of OA-associated matrix-degrading proteinases in chondrocytes. PMID: 22967398
    3. MATN3 may have the inherent ability to inhibit premature chondrocyte hypertrophy by suppressing BMP-2/Smad1 activity PMID: 25331953
    4. study will facilitate better awareness of the differential diagnoses that might be associated with the PSACH/MED spectrum and subsequent care of PSACH/MED patients PMID: 24312420
    5. Lack of COMP and matrilin 3 leads to increased deposition of TIMP-3, which causes partial inactivation of matrix metalloproteinases in bone, including MMP-13. PMID: 22378539
    6. matrilin-3 mutation associated with osteoarthritis does not affect collagen affinity but promotes the formation of wider cartilage collagen fibrils PMID: 20077500
    7. potential of matrilin-3 to modulate gene expression profile of primary chondrocytes; tested matrilin3-dependent induction of pro-inflammatory cytokines, inducible nitric oxide synthetase & cyclooxygenase-2, MMP1, -3 & -13, & matrilin-3 itself PMID: 19840795
    8. Expression of matrilin-3 during maturation of mouse skeletal tissues PMID: 12009334
    9. To assess the function of matrilin-3 during skeletal development, we have generated Matn-3 null mice; phenotypes of multiple epiphyseal dysplasia disorders are not caused by the absence of matrilin-3 in cartilage ECM. PMID: 14749384
    10. Matrilin-3 can be considered as an interface component, capable of interconnecting macromolecular networks PMID: 16287859
    11. The lack of Matn3 does not lead to postnatal chondrodysplasia but accounts for higher incidence of osteoarthritis. PMID: 16877353
    12. a matn3 mutation causes decreased chondrocyte proliferation and dysregulated apoptosis leading to epiphyseal dysplasia PMID: 17517694

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Strongly expressed in growing skeletal tissue such as epiphyseal growth plate or in bone undergoing growth and remodeling. In the bone, actively synthesized in osteoblasts and osteocytes. Expressed in cartilage of sternum, femur, vertebrae, trachea, artic
  • 数据库链接：

    KEGG: mmu:17182

    STRING: 10090.ENSMUSP00000020899

    UniGene: Mm.42226