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  4. Recombinant Mouse Non-histone chromosomal protein HMG-17 (Hmgn2)

Recombinant Mouse Non-histone chromosomal protein HMG-17 (Hmgn2)

  • 中文名称：
    小鼠Hmgn2重组蛋白
  • 货号：
    CSB-YP010570MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hmgn2重组蛋白
  • 货号：
    CSB-EP010570MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hmgn2重组蛋白
  • 货号：
    CSB-EP010570MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hmgn2重组蛋白
  • 货号：
    CSB-BP010570MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hmgn2重组蛋白
  • 货号：
    CSB-MP010570MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hmgn2
  • Uniprot No.：
  • 别名：
    Hmgn2; Hmg-17; Hmg17; Non-histone chromosomal protein HMG-17; High mobility group nucleosome-binding domain-containing protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-90
  • 氨基酸序列
    PKRKAEGDA KGDKTKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE KVPKGKKGKA DAGKDANNPA ENGDAKTDQA QKAEGAGDAK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.
  • 基因功能参考文献：
    1. Knockdown of Hmgn2 blocked the progesterone-induced differentiation of uterine stromal cells. Hmgn2 mediates the effects of estrogen on the expression of Cdh1, Cdh2 and Ctnnb1 in uterine epithelial cells. PMID: 29216626
    2. study demonstrates a role of HMGN2 in modulating specific gene expression and identifies beta-defensin-1, beta-defensin-3, and beta-defensin-4 as HMGN2 targets during the development of ICR mice treated with LPS PMID: 21594618
    3. The ectopic expression of Hmgn2 antagonizes mouse erythroid differentiation in vitro, which may be due to enhancement of DNA replication and/or blocking entry of mitosis at S-phase. PMID: 21988615
    4. each of the 4 amino acids in the R-S-RL motif are the only residues absolutely essential for anchoring HMGN protein to nucleosomes, both in vivo and in vitro. PMID: 18299391
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    HMGN family
  • 数据库链接：

    KEGG: mmu:15331

    STRING: 10090.ENSMUSP00000099612

    UniGene: Mm.319660