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  4. Recombinant Mouse Nuclear factor 1 C-type (Nfic)

Recombinant Mouse Nuclear factor 1 C-type (Nfic)

  • 中文名称：
    小鼠Nfic重组蛋白
  • 货号：
    CSB-YP015756MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nfic重组蛋白
  • 货号：
    CSB-EP015756MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nfic重组蛋白
  • 货号：
    CSB-EP015756MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nfic重组蛋白
  • 货号：
    CSB-BP015756MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nfic重组蛋白
  • 货号：
    CSB-MP015756MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nfic
  • Uniprot No.：
  • 别名：
    Nfic; Nuclear factor 1 C-type; NF1-C; Nuclear factor 1/C; CCAAT-box-binding transcription factor; CTF; Nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-439
  • 氨基酸序列
    MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE LLGEKAEVKQ KWASRLLAKL RKDIRPECRE DFVLAVTGKK APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER LVKAAACAHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSSSPRTGVG SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG ELQGHLAYDL NPASAGMRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY TSPNSPTSSS RNWTEDIEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT QHHRPVIAVH SGIARSPHPT SALHFPATPI LPQTASTYFP HTAIRYPPHL NPQDPLKDLV SLACDPATQQ PGPPALRPTR PLQTVPLWD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
  • 基因功能参考文献：
    1. An Nfic-Hhip-Hh signaling pathway is crucial for apical papilla growth and proper root formation. PMID: 26293299
    2. NFI-C acts as a regulator of the phased hepatocyte proliferation during liver regeneration. PMID: 25293436
    3. Results suggest that NFI-C acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in BMSCs. PMID: 24801901
    4. The purpose of this study was to identify the molecular interactions between NFI-C and TGF-beta1 signaling in mouse odontoblasts. PMID: 22195013
    5. The data suggest that zinc equilibrium is required for odontoblast differentiation and dentin formation during dentinogenesis through the nuclear accumulation and modulation of NFI-C. PMID: 22228435
    6. Nuclear factor I-C regulates TGF-{beta}-dependent hair follicle cycling PMID: 20729551
    7. Nfic(-/-) mice have unique tooth pathologies: molars lacking roots, thin and brittle mandibular incisors, and weakened abnormal maxillary incisors. PMID: 12529411
    8. first report demostrating the importance of NF1 proteins in the p53 gene activation in the mouse mammary gland; also, first time that p53 gene activation shown to be coupled to a specific, endogenously expressed NF1 isoform PMID: 12955085
    9. NF1-C2 protein is present in the epithelial compartment at the virgin stage and throughout mammary gland development and its transcripts are expressed in the whole epithelium at pregnancy as well as the lactation stage. PMID: 15637146
    10. the chromatin architecture of the promoters does not permit strong association of GR in the absence of NF1 PMID: 17186943
    11. may be a key regulator of root odontoblast differentiation and root formation PMID: 17760551
    12. Loss of the Nfic gene interferes with the formation of intercellular junctions that causes aberrant odontoblast differentiation and abnormal dentin formation. PMID: 19153194
    13. loss of Nfic leads to the suppression of odontogenic cell proliferation and differentiation and induces apoptosis of aberrant odontoblasts during root formation, thereby contributing to the formation of short roots PMID: 19386589

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    CTF/NF-I family
  • 组织特异性：
    Highest levels in skeletal muscle. Lower levels in heart, liver, kidney, lung and brain. Very low levels in testis and spleen.
  • 数据库链接：

    KEGG: mmu:18029

    STRING: 10090.ENSMUSP00000020461

    UniGene: Mm.426936