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  4. Recombinant Rat ADM (Adm)

Recombinant Rat ADM (Adm)

  • 中文名称：
    Recombinant Rat ADM(Adm),Yeast
  • 货号：
    CSB-YP001370RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat ADM(Adm),Yeast
  • 货号：
    CSB-EP001370RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat ADM(Adm),Yeast
  • 货号：
    CSB-EP001370RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat ADM(Adm),Yeast
  • 货号：
    CSB-BP001370RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat ADM(Adm),Yeast
  • 货号：
    CSB-MP001370RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Adm
  • Uniprot No.：
  • 别名：
    Adm; ADM [Cleaved into: Adrenomedullin; AM); Proadrenomedullin N-20 terminal peptide; ProAM N-terminal 20 peptide; PAMP; ProAM-N20)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    22-41
  • 氨基酸序列
    ARLDTSSQF RKKWNKWALS R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    AM and PAMP are potent hypotensive and vasodilatator agents.
  • 基因功能参考文献：
    1. Adrenomedullin expression is elevated after ischemic insult to the cerebral cortex and seems to be part of a CNS response mechanism to hypoxic injury. PMID: 11927154
    2. acute pressure overload induces a rapid increase in cardiac AM gene expression and in plasma AM concentrations PMID: 11954957
    3. Cerebral endothelial cells are a major source of adrenomedullin PMID: 11963825
    4. In vascular smooth muscle cells, ribozyme treatment lowered AM mRNA and peptide. Icv administration lowered hypothalamic AM and exaggerated drinking response in rats, demonstrating that AM is necessary for short-term control of water intake. PMID: 12010756
    5. plays a relevant role in the mechanisms underlying the maintenance of high growth rate during adrenal maturation PMID: 12060855
    6. endogenous ADM system located in the zona glomerulosa is upregulated in immature rats, and plays an important autocrine-paracrine role in the maintenance of the elevated growth rate during adrenal maturation PMID: 12060856
    7. adrenomedullin has an antiulcer effect in the rat which involves somatostatin related transmission PMID: 12126744
    8. Over-expression of adrenomedullin in the caudate-putamen and its changes in its intracellular location may be involved in the neuronal responses to brain ischemia with a possible neuroprotector role. PMID: 12165411
    9. adrenomedullin contributes to angiogenesis, functions as a growth factor, and helps regulate vascular tone during rat gestation PMID: 12193417
    10. results indicate that adrenomedullin (AM) inhibits doxorubicin-induced cardiac myocyte apoptosis through a cAMP-dependent mechanism and suggest that augmented production of AM by doxorubicin has an endogenous antiapoptotic effect PMID: 12193565
    11. The co-expression of Adm and its receptor in perineural fibroblasts suggests autocrine and/or paracrine modes of action of Adm in peripheral nerves. PMID: 12419522
    12. may play an important role in the regulation of blood pressure, the blood supply to the utero-placental unit and fetal development. PMID: 12491794
    13. the possible role of adrenomedullin in the regulation of electrolyte and fluid secretion in the epididymis PMID: 12606469
    14. The role of adrenomedullin in the transition from left ventricular hypertrophy to heart failure. PMID: 12623952
    15. endogenous adrenomedullin plays a physiological role in cultured rat ZG cells, by exerting a buffering action on their acute secretory response to Ang-II and K+ and by maintaining basal proliferative and apoptotic activities. PMID: 12630816
    16. increase of ADM level and the up-regulation of ADM and RAMP2 gene in myocardium and aorta may be significant in the pathogenesis of ischemic myocardiopathy PMID: 12732346
    17. increase in the secretion of adrenomedullin in the left ventricle and the left atria in the 5 week renovascular hypertensive rat. PMID: 12906842
    18. Results suggest that adrenomedullin plays a role in the regulation of water and electrolyte balance in animals chronically ingesting high levels of salt. PMID: 12913064
    19. AM expression was increased in the rat kidney in response to hypoxic and ischemic hypoxia in keeping with oxygen gradients. PMID: 14715486
    20. AM may play a role in modulating pulmonary hypertension in hypoxia induced pulmonary hypertension PMID: 14715505
    21. Up-regulated expression of AM and RAMP2 in afferent arterioles and glomeruli may be related to selective dilatation of glomerular capillary in acute phase of type 1 diabetes. PMID: 14717924
    22. ADM interacts with cyclooxygenase to yield prostanoids, which mediate its negative inotropic effect in LPS-treated rat ventricular myocytes. PMID: 14766677
    23. in spontaneously hypertensive rats, the local concentration and action of ADM in the tissues may be differentially regulated by neutral endopeptidase. PMID: 15005274
    24. Adm plays a protective role as an endogenous antioxidant in Ang II-induced vascular injury. PMID: 15070851
    25. c-myc transactivates rat and human adrenomedullin genes and accelerates the degradation rate of adrenomedullin mRNA. PMID: 15192039
    26. Antagonism of adrenomedullin in rats during early pregnancy caused fetoplacental growth restriction through the activation of mitochondrial apoptotic pathways. PMID: 15229133
    27. Lysophosphatidic acid (LPA) stimulates the adventitia to produce and secrete ADM, which in turn regulates the vascular biological effects of LPA. PMID: 15256273
    28. adrenomedullin produced in the brain may be an important neuromodulator of the hormonal stress response. PMID: 15271873
    29. Adrenomedullin and its receptor component (CRLR/RAMP2) mRNAs were concomitantly expressed in various adipose tissues, whose tissue-specific upregulation was induced during the development of obesity PMID: 15315911
    30. aldosterone stimulates rat cardiac fibroblasts to produce and secrete ADM, which in turn regulates the proliferation-induced effects of aldosterone in these cells PMID: 15511634
    31. Adrenomedullin modulates MIF secretion and cytokine production and plays important roles in both the initiation and propagation of the inflammatory response PMID: 15576460
    32. ADM is highly induced in variety of lung cell types in this model of acute lung injury by combination of hypoxia and LPS, suggesting an essential role for this mediator in this syndrome. PMID: 15579624
    33. Data show that adrenomedullin and receptor-activity-modifying proteins increased during the resolution phase of increased mesangial proliferation in Thy.1 glomerulonephritis, but not during the mesangial proliferative phase. PMID: 15619030
    34. induction of RAMP2 and RAMP3 contributes to the increased responsiveness to adrenomedullin in failing cardiomyocytes PMID: 15623431
    35. Data suggest that intracardiac adrenomedullin and calcitonin receptor-like receptor/receptor activity-modifying proteins (RAMP2 and RAMP3) complexes, are upregulated in volume overload-induced cardiac hypertrophy. PMID: 15680493
    36. results suggest that the biosynthesis and secretion of adrenomedullin(AM) may be increased in cardiovascular tissues of rats injected with lipopolysaccharide, and that AM may play multiple roles in inflammation PMID: 15752540
    37. Study suggests that the increased adrenomedullin receptor signaling mediated the many, but not all, tumor necrosis factor-alpha-induced activities, contributing to peripheral sensitization in neuropathic pain. PMID: 27184601
    38. Rat Alveolar NR8383 Macrophage cell line NR8383 is both a source and a target of the calcitonin peptide family members, ADM, ADM2, and CGRP. PMID: 27737007
    39. Levels of adrenomedullin peptide fragments respond to pulmonary remodeling in pulmonary hypertension. PMID: 25990643
    40. Findings demonstrate a dysregulation of cerebellar adrenomedullin-system during hypertension, and suggest that cerebellar drenomedullin plays an important role in the regulation of blood pressure. PMID: 26259851
    41. AM/AMBP-1 accelerated wound healing by promoting angiogenesis, collagen deposition and remodeling PMID: 25781901
    42. Data suggest that stimulation of adrenomedullin/adrenomedullin receptor signaling enhances trophoblast stem cell differentiation; this stimulation involves CALCRL (calcitonin receptor-like receptor) and RAMP2 (receptor activity-modifying protein 2). PMID: 25061099
    43. Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection. PMID: 24505304
    44. expression of adrenomedullin and the calcitonin receptor-like receptor system in the rat heart and sensory ganglia in experimentally-induced long-term diabetes PMID: 24177018
    45. AM in the CSF contributes to the modulation of acute inflammatory pain in the formalin test. PMID: 23939287
    46. Epididymal fat and soleus muscles from rat were incubated with ADM at concentration of 100 nM for the study of the gene expression and secretion of tumour necrosis factor (TNF-alpha), EDN-1, leptin, adiponectin, interleukin 1beta (IL-1beta), and IL-6. PMID: 22956308
    47. This study found that adrenomedullin (ADM), acting through the ADM receptor, had critical roles during preimplantation. PMID: 22365702
    48. Ethanol consumption increases blood pressure and the expression of adrenomedullin in the vasculature and reduces the relaxation induced by this peptide in the mesenteric arterial bed. PMID: 22021555
    49. Data suggest that developmental adrenomedullin gene expression in various organs follows different patterns; in kidney, adrenomedullin expression may be related to development of the organ. PMID: 22042486
    50. adrenomedullin showed beneficial effects in the restoration of vascular function through the regulation of vasoactive products derived from COX-2 and iNOS PMID: 21958875

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Adrenomedullin family
  • 组织特异性：
    Expressed in adrenal glands, lung, kidney, heart, spleen, duodenum and submandibular glands.
  • 数据库链接：

    KEGG: rno:25026

    STRING: 10116.ENSRNOP00000035811

    UniGene: Rn.10232