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  4. Recombinant Rat Calcitonin gene-related peptide 1 (Calca)

Recombinant Rat Calcitonin gene-related peptide 1 (Calca)

  • 中文名称：
    Recombinant Rat Calcitonin gene-related peptide 1(Calca),Yeast
  • 货号：
    CSB-YP004434RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Calcitonin gene-related peptide 1(Calca),Yeast
  • 货号：
    CSB-EP004434RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Calcitonin gene-related peptide 1(Calca),Yeast
  • 货号：
    CSB-EP004434RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Calcitonin gene-related peptide 1(Calca),Yeast
  • 货号：
    CSB-BP004434RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Calcitonin gene-related peptide 1(Calca),Yeast
  • 货号：
    CSB-MP004434RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Calca
  • Uniprot No.：
  • 别名：
    Calca; Calc; Calcitonin gene-related peptide 1; Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    83-119
  • 氨基酸序列
    SCNTATCV THRLAGLLSR SGGVVKDNFV PTNVGSEAF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
  • 基因功能参考文献：
    1. CGRP gene-modified rat bone mesenchymal stem cells show better osteogenic differentiation capacity. PMID: 29846865
    2. Remote hind limb preconditioning stimulus probably activates TRPV1 channels which subsequently induces CGRP release to produce cardioprotective effects. PMID: 28599085
    3. calcitonin and TGF-beta have roles in cartilage degeneration and nociception in an experimental rat model of osteoarthritis PMID: 27345362
    4. data suggest that CGRP can partly protect AECII cells from hyperoxia-induced injury, and the upregulation of CGRP may be a potential therapeutic approach with which to combat hyperoxia-induced lung injury, which may be associated with the activation of the SHH signaling pathway. PMID: 28560441
    5. findings suggest that the 17beta-estradiol-regulated release of CGRP could at least in part provide a rational explanation for the difference of gender in the visceral pain sensitivity. PMID: 27579553
    6. In muscle injuries, up-regulation of CGRP in dorsal root ganglia continued for two weeks after injury. PMID: 26930007
    7. Rat Alveolar NR8383 Macrophage cell line NR8383 is both a source and a target of the calcitonin peptide family members, ADM, ADM2, and CGRP. PMID: 27737007
    8. Tyrosine phosphorylation of NR2B decreased the mechanical threshold and increased migraine attacks via upregulated CGRP expression in the rat model of chronic migraines (CM). Thus, tyrosine phosphorylation of NR2B may be a potential therapeutic target for treatment of CM PMID: 28393079
    9. CGRP mediated osteoblastogenesis of bone marrow stromal stem cells proceeds via the Wnt/beta-catenin pathway. PMID: 27082317
    10. CGRP may play an important role in developing the collateral circulation. PMID: 27470397
    11. The results demonstrated that density of CGRP reached peak on the 21st day after surgery and most of the CGRP expression located surrounding the interface of allograft and fibrous tissue where the cells differentiate into osteoblasts, indicating that CGRP might be involved in the process of bone formation and absorption. PMID: 27990431
    12. Urethral endocrine cells may release serotonin in response to luminal stimuli; these cells and CGRP-immunoreactive nerves may regulate each other by an axon reflex mechanism. PMID: 27939448
    13. lumbar disc herniation upregulates microglial Iba1 activity and CGRP expression in many adjacent and ipsilateral lumbar spinal segments PMID: 26713069
    14. Periodontal CGRP plays an important role in pain transmission and modulation following experimental tooth movement. PMID: 26164378
    15. CGRP gradually up-regulates expression levels of osteoporotic differentiation-related genes including alkaline phosphatase. PMID: 25563479
    16. Correlation between algogenic effects of CGRP and activation of trigeminal vascular system, in an in vivo experimental model of nitroglycerin-induced sensitization PMID: 24998872
    17. Studied the effect of type 2 diabetes induced by high-fat diet and streptozotocin, and the effect of endurance training on basal circulating levels of calcitonin gene-related peptide (CGRP) and lactate. PMID: 25219961
    18. these findings suggest that adipose tissue is a physiological target for alpha-CGRP. PMID: 24887115
    19. Immunohistochemistry showed that in the DRGs, TRPV1-, CGRP-, and SP-immunoreactive neurons were mostly small- and medium-sized and the proportion of TRPV1- and CGRP-labeled neurons PMID: 24877063
    20. PACAP-38 cause release of CGRP from trigenimal nucleus caudalis but not from trigeminal ganglion. PMID: 24508136
    21. Suggest that nerve compression plus nucleus pulposus application induces changes in CGRP expression in the superficial and deep laminae, and these changes are partly responsible for disc herniation pain. PMID: 24384662
    22. Prolonged hypocalcemic effect by pulmonary delivery of calcitonin loaded poly(methyl vinyl ether maleic acid) bioadhesive nanoparticles. PMID: 24701588
    23. that sensory information from the larynx might be conveyed by many CGRP-ir neurons located in the superior glossopharyngeal-jugular ganglion complex by way of the superior and recurrent laryngeal nerve. PMID: 24269509
    24. CGRP and its receptor are widely distributed in pain-related structures in the brain, including the trigeminovascular system. PMID: 24321404
    25. The majority of sensory dorsal root ganglia neurons innervating the subchondral bone of the distal femur were calcitonin gene-related peptide-IR and tyrosine receptor kinase A-IR PMID: 23821557
    26. CGRP causes long-lasting non-selective arterial smooth muscle relaxation that may add to the neuropeptide being a physiological antagonist of arterial effects of ET-1. PMID: 24140435
    27. CGRP is expressed in the nerves supplying rat dental tissues. PMID: 24328744
    28. The increases of the cell apoptosis in the retina may be related to the down-regulation of endogenous CGRP in diabetes. PMID: 24051030
    29. These data suggest that CGRP is expressed in C-fibers and may act on A-fibers, rodent mast cells, and vascular smooth muscle cells that express the CGRP receptor. PMID: 23958278
    30. signalling via CGRP receptors may be enhanced through endogenous nitric oxide production in a rat model of migraine PMID: 24004534
    31. Data indicate that the proportion of calcitonin gene-related peptide CGRP)-immunoreactive dorsal root ganglion neurons in the IVD injury group was significantly higher than the corresponding proportion in the sham group. PMID: 23649215
    32. these observations support the hypothesis that genotype-selective phenotypic switching of CGRP expression in Abeta afferents following nerve injury is a fundamental mechanism of neuropathic tactile allodynia. PMID: 24076003
    33. It is concluded that the expression of gross and surface CRLR and RAMP1 were differentially regulated in primary neuronal cultures following morphine treatments, indicating the involvement of CGRP receptor in morphine associated functions. PMID: 23570731
    34. These data demonstrate that hypothalamic aminoprocalcitonin is involved in control of energy balance and that its anorexigenic effects are mediated through the melanocortin system. PMID: 23571710
    35. mRNA and protein levels of CGRP in dorsal root ganglion (DRG) in the DM/TENS group were higher than those in the DM group. TENS also significantly up-regulated the cAMP content in the bladder body and base compared with diabetic rats PMID: 23468996
    36. Data indicate that at C7 facet joint, 54.4% +/- 15.3% of neurons were CGRP-positive, whereas only 41.5% +/- 5.4% of all neurons were CGRP-positive and this difference was significantsignificant (P = 0.0084). PMID: 23324931
    37. may have an important role in the early phase of liver regeneration PMID: 23218524
    38. These results indicate that CGRP may participate in trigeminal nociceptive system sensitization by induced increase in TRPV1 PMID: 23123284
    39. NXN-188 inhibits CGRP release from migraine-relevant cephalic tissues. PMID: 23155193
    40. The reciprocal changes in SST and histamine secretion in gastric Helicobacter infection were due to release of CGRP from sensory neurons. PMID: 23392237
    41. Both the number of CGRPi neurons in the vestibular efferent nucleus and expression level in the vestibular nucleus increased significantly in rats with motion sickness compared to that of controls PMID: 23056625
    42. Endothelin converting enzyme 1 (ECE1) regulated the resensitization of responses to CGRP in rat mesenteric artery smooth muscle cells and mesenteric arteries, hence, ECE1 inhibitors may attenuate an important vasodilatory pathway implicated in headaches PMID: 22881710
    43. The effects of nerve growth factor (NGF) or neurotrophin-3 (NT-3) on the expression of mRNAs for PPT, CGRP, NF-200, and MAP-2 was analyzed by real time-PCR assay. PMID: 22763971
    44. The signaling pathways in cystitis- or NGF-induced CGRP expression reveals that the activation (phosphorylation) of extracellular signal-regulated protein kinase (ERK)5. PMID: 22742729
    45. A complete foot sole biopsy was taken from the injured paw and processed for Calcitonin Gene-Related Peptide (CGRP) immunohistochemistry. PMID: 22935198
    46. Critical role of calcitonin gene-related peptide receptors in cortical spreading depression. PMID: 23112192
    47. The hyperoxia-induced acute lung injury is associated with both oxidative stress and inflammatory responses, and CGRP may ameliorate the hyperoxia-induced lung injury by down-regulating these processes. PMID: 22706400
    48. After traumatic injury to periodontal ligament, CGRP nerve fibers appear in close vicinity of small and large receptor activity modifying protein (RAMP)1 cells at 5-7 days. PMID: 22038237
    49. immunoreactive fibers were frequently found intraganglionic in the SPG in the vicinity of neurons. PMID: 22208649
    50. More CGRP sensory nerve fibers and dorsal root ganglia neurons are found innervating muscle in the midline approach area than in the Wiltse paraspinal approach area. PMID: 21289592

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Calcitonin family
  • 数据库链接：

    KEGG: rno:24241

    UniGene: Rn.90085