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  4. Recombinant Rat Nuclear receptor subfamily 1 group I member 2 (Nr1i2)

Recombinant Rat Nuclear receptor subfamily 1 group I member 2 (Nr1i2)

  • 中文名称：
    大鼠Nr1i2重组蛋白
  • 货号：
    CSB-YP889932RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nr1i2重组蛋白
  • 货号：
    CSB-EP889932RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nr1i2重组蛋白
  • 货号：
    CSB-EP889932RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nr1i2重组蛋白
  • 货号：
    CSB-BP889932RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nr1i2重组蛋白
  • 货号：
    CSB-MP889932RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Nr1i2; Pxr; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PXR; Pregnane X receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-431
  • 氨基酸序列
    MRPEERWNHV GLVQREEADS VLEEPINVDE EDGGLQICRV CGDKANGYHF NVMTCEGCKG FFRRAMKRNV RLRCPFRKGT CEITRKTRRQ CQACRLRKCL ESGMKKEMIM SDAAVEQRRA LIKRKKREKI EAPPPGGQGL TEEQQALIQE LMDAQMQTFD TTFSHFKDFR LPAVFHSDCE LPEVLQASLL EDPATWSQIM KDSVPMKISV QLRGEDGSIW NYQPPSKSDG KEIIPLLPHL ADVSTYMFKG VINFAKVISH FRELPIEDQI SLLKGATFEM CILRFNTMFD TETGTWECGR LAYCFEDPNG GFQKLLLDPL MKFHCMLKKL QLREEEYVLM QAISLFSPDR PGVVQRSVVD QLQERFALTL KAYIECSRPY PAHRFLFLKI MAVLTELRSI NAQQTQQLLR IQDTHPFATP LMQELFSSTD G
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
  • 基因功能参考文献：
    1. the results of combined analyses suggest that PXR's effects are due to transcriptional and post-transcriptional regulation with alteration of nongenotoxic signaling pathways and energy homeostasis. PMID: 28825834
    2. In epileptic rats, P-glycoprotein expression regulates pregnane X receptor up-regulation in brain. PMID: 28303499
    3. Metabolism of methiocarb and carbaryl alters PXR agonist activity. PMID: 27665777
    4. Drug-mediated activation of the pregnane X receptor reduced these adverse changes in rats, suggesting that the pregnane X receptor is a viable drug target to reduce ischaemic-type biliary lesions in recipients of liver transplants PMID: 26302150
    5. PXR in the midbrain may be required for the observed increase in 3alpha-5alpha-THP during proestrus, which has subsequent effects on motivated, reproductive behaviors. PMID: 23634744
    6. Following ethyl tertiary-butyl ether administration, PXR is activated along with tumorigenesis and oxidative stress. PMID: 24090815
    7. Results indicate that pregnane X receptor (PXR) represents a flow-activated detoxification system to protect endothelial cells (ECs) against damage by xeno- and endobiotics. PMID: 23878263
    8. Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress. PMID: 22166712
    9. A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16alpha-carbonitrile. PMID: 21311750
    10. Repeated MDMA use in combination with other therapeutic drugs, may result in adverse drug-drug interactions via PXR and/or CYP3A inhibition. PMID: 21402137
    11. PXR (Nr1i2) expression is required for Bcl-2 and Bcl-xL up-regulation upon PXR activators treatment in human and rat hepatocytes. PMID: 16085054
    12. the blood-brain barrier in 8-week-old rats lacks ABCB1 regulation via pregnane X receptor PMID: 17919779
    13. the species-specific impact of cyclic AMP-dependent protein kinase signaling on pregnane x receptor and provide a molecular explanation of cyclic AMP-dependent protein kinase-mediated repression of human pregnane x receptor activity. PMID: 19141612
    14. Evidence for the involvement of PXR in transcriptional effects upon perfluoroalkyl acid exposure is reported. PMID: 19162173
    15. PXR mRNA levels did not differ in the large-for-gestational-age rats PMID: 19435144

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 数据库链接：

    KEGG: rno:84385

    STRING: 10116.ENSRNOP00000003934

    UniGene: Rn.207164