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中文名称:大鼠骨钙素/骨谷氨酸蛋白(OT/BGP)酶联免疫试剂盒
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货号:CSB-E05129r
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规格:96T/48T
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价格:¥3900/¥2500
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其他:
产品详情
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别名:Bglap ELISA Kit; Bglap2 ELISA Kit; Osteocalcin ELISA Kit; Bone Gla protein ELISA Kit; BGP ELISA Kit; Gamma-carboxyglutamic acid-containing protein ELISA Kit
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缩写:BGLAP
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Uniprot No.:
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种属:Rattus norvegicus (Rat)
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样本类型:serum, plasma,tissue homogenates.
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检测范围:125 pg/mL- 8000 pg/mL
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灵敏度:31.25 pg/mL
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反应时间:1-5h
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样本体积:50-100ul
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检测波长:450 nm
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研究领域:Metabolism
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测定原理:quantitative
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测定方法:Sandwich
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数据处理:
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货期:3-5 working days
引用文献
- The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg F Zhu,European journal of nutrition,2024
- Bone Developmental Toxicology Studies of Cadmium Chloride in Juvenile Sprague Dawley Rats S Wang,/,2024
- An aqueous extract of Prunella vulgaris L. ameliorates cadmium-induced bone loss by promoting osteogenic differentiation in female rats L Mo,Food and chemical toxicology,2023
- Morinda officinalis polysaccharide regulates rat bone mesenchymal stem cell osteogenic–adipogenic differentiation in osteoporosis by upregulating miR-21 and activating the PI3K/AKT pathway PY Wu,Kaohsiung journal of medical sciences,2023
- Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy Y Song,Journal of Visualized Experiments,2023
- Correlation between Antioxidant and Anti-Osteoporotic Activities of Shilajit Loaded into Chitosan Nanoparticles and Their Effects on Osteoporosis in Rats FA Alshubaily,Polymers,2022
- Tianchang Capsule prevents ovariectomy induced osteoporosis in rats H CHEN,Food Science and Technology,2021
- Metabolomics and physiological analysis of the effect of calcium supplements on reducing bone loss in ovariectomized rats by increasing estradiol levels H Mao,Nutrition & metabolism,2021
- MiR-133a is a potential target for arterial calcification in patients with end-stage renal disease S Li,International Urology and Nephrology,2021
- Crosstalk between histone and DNA methylation mediates bone loss in hind limb unloading L Bing,Journal of Bone and Mineral Research,2021
- Edible Bird’s Nest Attenuates Menopause-Related Bone Degeneration in Rats via Increaing Bone Estrogen-Receptor Expression Hou Z,Chinese Journal of Integrative Medicine,2019
- Possible osteoprotective effects of myricetin in STZ induced diabetic osteoporosis in rats Xiaozhou Ying, et al,European Journal of Pharmacology,2019
- Toll-like receptor 4 knockout protects against diabetic-induced imbalance of bone metabolism via autophagic suppression Yongze Zhang, et al,Molecular Immunology,2019
- Exosomal hsa-miR-21-5p derived from growth hormone-secreting pituitary adenoma promotes abnormal bone formation in acromegaly Yuanyuan Xiong, et al,Translational Research,2019
- Evaluation of the osteoprotective potential of whey derived-antioxidative (YVEEL) and angiotensin-converting enzyme inhibitory (YLLF) bioactive peptides in ovariectomised rats Masum Pandey.et al,FOOD & FUNCTION,2018
- Soybean-Hop Alleviates Estrogen Deficiency-Related Bone Loss and Metabolic Dysfunction in Ovariectomized Rats Fed a High-Fat Diet Dasom Noh.et al,Molecules,2018
- Animal model having hypoparathyroidism and method for producing the same Han Su.et al,/,2018
- Advanced oxidation protein products accelerated the bone loss and weakened bone strength in ovariectomised rats Shuai Zheng.et al,Int J Clin Exp Pathol ,2017
- Tetrahydroxystilbene glucoside isolated from Polygonum multiflorum Thunb. demonstrates osteoblast differentiation promoting activity Yayuan Zheng.et al,Experimental and Therapeutic Medicine,2017
- Effects of Fructus Chaenomelis on longitudinal bone growth in adolescent rats hun Lee C.et al, International Journal of Phytomedicine,2015
- Effects of Aqueous Extract of Phyllostachyos Caulis in Taeniam on Longitudinal Bone Growth in Adolescent Rats Chung YH. et al,Planta Med.,2016
- Effects of pro-inflammatory cytokines on mineralization potential of rat dental pulp stem cells Xuechao Yang et al,Journal of Tissue Engineering and Regenerative Medicine,2011
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问答及客户评论
I would like to know what wavelength this product needs to be read at to make sure we have the appropriate filters. Also, we have some mouse cells lines, will this product work for those cell lines as well?
We use TMB substrate. The detection wavelength must be 450nm. The absorbance value will be very good at this wavelength. Considering there may be scratches at the bottom of the vial when you add samples, we suggest you use dual wavelength( detection wavelength and correction wavelength).
We don't suggest you use this kit to test mouse cells lines. If you want to test it, you can do a pretest first.
靶点详情
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功能:Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
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基因功能参考文献:
- These data suggest that Undercarboxylated osteocalcin may have other effects on skeletal muscle in addition to its insulin sensitizing effect. PMID: 27291707
- Uncarboxylated osteocalcin potentiates insulin secretion, inhibits Kv channels and increases [Ca(2+)]i. PMID: 27746193
- This rat model of complete loss of osteocalcin provides a platform for further understanding the role of osteocalcin in disease. PMID: 27483347
- gamma-Carboxylase inhibition prevents osteocalcin carboxylation and protects against diabetic cardiomyopathy, possibly through direct action on upregulated G protein-coupled receptor family C group 6 member A and indirectly via adiponectin. PMID: 27488359
- Bone Gla Protein PMID: 25185647
- In primary adipocytes, both carboxylated and uncarboxylated osteocalcin increased basal and insulin-stimulated glucose transport. PMID: 24554534
- The physiological changes associated with estrous cycle stage were not sufficient to cause a detectable difference in carboxylated or undercarboxylated osteocalcin concentrations in this study. PMID: 23817840
- Osteocalcin (OC)-containing neurons are distributed throughout the cerebellar nuclei; OC may play a role in modulating the neuroprotective function of osteopontin. PMID: 22552891
- warfarin impaired the carboxylation of osteocalcin in rats. Factor Xa inhibitor edoxaban at or higher doses than needed for an antithrombotic effect sustained the circulating Gla-osteocalcin level. PMID: 22999414
- results suggest that under some physiological conditions the oncoprotein MDM2 may cooperate with p53 to regulate the osteocalcin gene during osteoblastic differentiation. PMID: 22405968
- These data are strongly in support of Sp1 as an essential transcription factor required for Osx recruitment and transactivation of the OCN promoter. PMID: 21820092
- purified Bone Gla Protein (BGP) resulted in stabilization of hypoxia-inducible factor 1alpha (HIF-1alpha) in chondrocytes and vascular smooth muscle cells PMID: 21757657
- The mechanism of high glucose induced calcification in vascular smooth muscle cells may be due to the increased expression of cbfalpha-1 and OC. PMID: 21302441
- functional link between vitamin D-dependent bone tissue-specific transcription and histone acetylation at osteocalcin locus PMID: 11893738
- the VDRE in the distal region of the OC gene promoter is refractory to binding of the VDR-RXR complex when organized in a nucleosomal context PMID: 11964167
- deltaEF1 suppresses expression of the endogenous osteocalcin gene PMID: 12193549
- acetylation of histones H3 and H4 is functionally coupled to the chromatin remodeling events that mediate the developmental induction of osteocalcin gene transcription in bone cells PMID: 12554783
- Type I collagen promotes the activity of dentin formation by dental pulp cells by down-regulating Dmp-1 gene expression and up-regulating osteocalcin gene expression. PMID: 12647294
- A human vitamin D receptor-glucocorticoid receptor DNA-binding domain chimera is functional on rat osteocalcin vitamin D-responsive element with only conservative change of lys-49 to arg, and of negatively charged glu-53 to basic amino acid (lys or arg). PMID: 12960019
- Data show that in osteoblastic cells, the vitamin D receptor interacts directly with Runx2, and that this interaction contributes significantly to vitamin D3-dependent enhancement of the osteocalcin promoter. PMID: 15456860
- Results describe gene regulation by Dlx3 in relation to that of Msx2 and Dlx5 during osteoblast differentiation. PMID: 15456894
- Ocn is a Nurr1 target gene, which positions Nurr1 in the core of transcriptional factors regulating osteoblastic gene expression PMID: 15485875
- OC-IR nerve fibers in the circumvallate papilla mainly originated from the petrosal ganglion. PMID: 15621021
- Osteonectin (ON) and osteocalcin (OC) was used as osteoblast markersand assessed using an indirect immunoperoxidase. technique. PMID: 16443258
- CEBP-beta-dependent recruitment of SWI/SNF activity is required for chromatin remodeling and transcriptional activity of the bone-specific osteocalcin gene PMID: 16772287
- specific protein-DNA and protein-protein interactions that occur within the context of the OC gene promoter in osteoblastic cells stabilize the preferential association of the VDR-SRC-1 complex PMID: 17218095
- These results support a model where VDR preferentially recruits SRC-1 to enhance bone-specific OC gene transcription. PMID: 17786964
- These data suggest that long-term reduction in bone OC levels may induce the formation of immature bone, which is easily resorbed with changes in bone metabolism such as ovariectomy, and that OC may be one of the factors affecting bone turnover. PMID: 17968486
- TFIIA gamma together with ATF4 and Runx2 stimulates osteocalcin promoter activity and endogenous mRNA expression. PMID: 18171674
- Biomineralization followed secretion of osteocalcin, which may reflect early osteoblastic differentiation of cultured mesenchymal stem cells under osteoinductive conditions. PMID: 19191495
- The Notch-responsive Hes-1 protein is capable of repressing osteocalcin gene transcription in osteoblastic cells through an E-box in the proximal promoter. PMID: 19670267
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亚细胞定位:Secreted.
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蛋白家族:Osteocalcin/matrix Gla protein family
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数据库链接:
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