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psmE3

Proteasome activator complex subunit 3 is a protein in humans that is encoded by PSME3 gene. Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

psmE3 Antibodies

psmE3 for Homo sapiens (Human)

psmE3 Proteins

psmE3 Proteins for Sus scrofa (Pig)

psmE3 Proteins for Homo sapiens (Human)

psmE3 Proteins for Mus musculus (Mouse)

psmE3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

psmE3 Proteins for Gallus gallus (Chicken)

psmE3 Proteins for Pongo abelii (Sumatran orangutan)

psmE3 Proteins for Dictyostelium discoideum (Slime mold)