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  4. Human αN-acetylglucosaminidase,αNAG ELISA Kit

Human αN-acetylglucosaminidase,αNAG ELISA Kit

  • 中文名称：
    人αN已酰氨基葡糖苷酶(αNAG)酶联免疫试剂盒
  • 货号：
    CSB-E09456h
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：

产品详情

  • 产品描述：
    人αN已酰氨基葡糖苷酶(αNAG)酶联免疫试剂盒（CSB-E09456h）为竞争法ELISA试剂盒，定量检测样本中的NAGLU含量。NAGLU 是一个重要靶点。它与多种生理和病理过程相关，在人体代谢等方面发挥关键作用。目前研究聚焦于其在疾病发生发展中的机制，比如某些遗传疾病与之关联，通过深入研究其作用机制有望开发出针对性的治疗药物和手段。适用于细胞生物学、病理机制研究及药物开发中酶活性变化的动态监测，可为代谢性疾病模型构建、基因功能验证等实验提供可靠数据支持。本品仅用于科研，不用于临床诊断，产品具体参数及操作步骤详见产品说明书。
  • 别名：
    Alpha N acetylglucosaminidase ELISA Kit; alpha N acetylglucosaminidase; lysosomal ELISA Kit; Alpha-N-acetylglucosaminidase 77 kDa form ELISA Kit; ANAG ELISA Kit; ANAG_HUMAN ELISA Kit; CMT2V ELISA Kit; MPS IIIB ELISA Kit; MPS3B ELISA Kit; N acetyl alpha glucosaminidase ELISA Kit; N acetylglucosaminidase; alpha ELISA Kit; N-acetyl-alpha-glucosaminidase ELISA Kit; NAG ELISA Kit; NAGLU ELISA Kit; UFHSD 1 ELISA Kit; UFHSD ELISA Kit; UFHSD1 ELISA Kit
  • 缩写：
    NAGLU
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
  • 检测范围：
  • 灵敏度：
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Neuroscience
  • 测定原理：
    quantitative
  • 测定方法：
    Competitive
  • 精密度：
  • 线性度：
  • 回收率：
  • 标准曲线：
  • 数据处理：
  • 货期：
    3-5 working days

产品评价

靶点详情

  • 功能：
    Involved in the degradation of heparan sulfate.
  • 基因功能参考文献：
    1. findings show that the NAGLU protein consists of a precursor and a mature form and that in slowly progressing mucopolysaccharidosis type IIIB patients' fibroblasts only the precursor protein is present at 37 degrees ; culturing at lower temperatures resulted in the formation of the mature, enzymatically active form, due to higher mRNA levels and improved processing PMID: 28751108
    2. CSF enzyme activity levels for either SGSH (in MPS IIIA subjects) or NAGLU (in MPS IIIB) significantly differed from normal controls. Several other behavioral or functional measures were found to be uninformative in this population, including timed functional motor tests. PMID: 27590925
    3. Mutation in NAGLU gene is associated with atypical mucopolysaccharidosis IIIB. PMID: 28306536
    4. in the current meta-analysis, based on ten prospective studies involving 29366 participants, we evaluated the role of urinary tubular injury markers (NGAL, KIM-1 and NAG) in predicting clinical outcomes including CKD stage 3, end stage renal disease and mortality. PMID: 27907168
    5. Mutations in NAGLU gene is associated with idiopathic progressive cognitive decline. PMID: 25466957
    6. Plasma NAG correlates with gastrointestinal cancer outcomes. PMID: 25040106
    7. study reports that carriers from two families of a severe pathogenic mutation in NAGLU develop a late dominant painful axonal sensory neuropathy. PMID: 25818867
    8. A modified recombinant NAGLU fused to the receptor-binding motif of insulin-like growth factor (IGF)-II enhances its ability to enter cells using the mannose 6-phosphate receptor, which is the receptor for IGF-II at a different binding site. PMID: 24266751
    9. The research may enrich the mutation spectrum of the NAGLU gene in the Chinese population and help us further in understanding the pathogenesis of MPS IIIB. PMID: 23380547
    10. Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients. PMID: 22935351
    11. This study suggests a possible role of NAGLU in susceptibility to PD while extending evidence for alpha-synuclein aggregation in the brain in lysosomal storage disorders. PMID: 22102531
    12. We have identified an 1146 bp intragenic deletion of the NAGLU gene within consanguineous parents having two children affected with Sanfilippo syndrome type B. PMID: 20138557
    13. Molecular genetics of mucopolysaccharidosis type IIIA and IIIB: Diagnostic, clinical, and biological implications PMID: 11668611
    14. Sanfilippo syndrome (subtypes A and B) in Turkey: identification of novel mutations in SGSH and NAGLU PMID: 11793481
    15. The NAGLU gene in 11 Mucopolysaccharidosis type IIIB Portuguese patients, was examined, having identified five novel (M1K, W147X, G304V, S522P, and R533X) and four previously reported mutations (W168X, R234C, R565W and R643C). PMID: 18218046

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  • 相关疾病：
    Mucopolysaccharidosis 3B (MPS3B); Charcot-Marie-Tooth disease 2V (CMT2V)
  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    Glycosyl hydrolase 89 family
  • 组织特异性：
    Liver, ovary, peripheral blood leukocytes, testis, prostate, spleen, colon, lung, placenta and kidney.
  • 数据库链接：

    HGNC: 7632

    OMIM: 252920

    KEGG: hsa:4669

    STRING: 9606.ENSP00000225927

    UniGene: Hs.50727