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ALDH4A1 Antibody

  • 中文名称：
    ALDH4A1兔多克隆抗体
  • 货号：
    CSB-PA252846
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA252846(ALDH4A1 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA252846(ALDH4A1 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: CSB-PA252846(ALDH4A1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P30038
  • 基因名：
    ALDH4A1
  • 别名：
    AL4A1_HUMAN antibody; aldehyde dehydrogenase 4 antibody; aldehyde dehydrogenase 4 family; member A1 antibody; Aldehyde dehydrogenase family 4 member A1 antibody; Aldehyde dehydrogenase; family 4; subfamily A; member 1 antibody; ALDH4 antibody; aldh4a1 antibody; Delta 1 pyrroline 5 carboxylate dehydrogenase; mitochondrial antibody; Delta-1-pyrroline-5-carboxylate dehydrogenase antibody; L-glutamate gamma-semialdehyde dehydrogenase antibody; mitochondrial antibody; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase antibody; P5C dehydrogenase antibody; P5CD antibody; P5CDh antibody; P5CDhL antibody; P5CDhS antibody; Pyrroline-5-carboxylate dehydrogenase antibody; RP11 128M10.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ALDH4A1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
  • 基因功能参考文献：
    1. the impact of the hyperprolinemia-associated mutation of Ser352 to Leu on the structure and catalytic properties of the P5CDH PMID: 22516612
    2. ALDH4 is a p53-inducible gene with a protective role in cellular stresses PMID: 14986171
    3. ALDH4 is transcriptionally induced by p53. PMID: 14986171
  • 相关疾病：
    Hyperprolinemia 2 (HYRPRO2)
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Aldehyde dehydrogenase family
  • 组织特异性：
    Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta, lung and pancreas.
  • 数据库链接：

    HGNC: 406

    OMIM: 239510

    KEGG: hsa:8659

    STRING: 9606.ENSP00000290597

    UniGene: Hs.77448