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  4. Acetyl-NRIP1 (Lys158) Antibody

Acetyl-NRIP1 (Lys158) Antibody

  • 中文名称：
    Acetyl-NRIP1 (Lys158)兔多克隆抗体
  • 货号：
    CSB-PA433041
  • 规格：
    ￥880
  • 图片：
    • Western blot analysis of 293T using Acetyl-RIP140 (K158) antibody. Antibody was diluted at 1:500. Secondary antibody was diluted at 1:20000
  • 其他：

产品详情

  • Uniprot No.：
    P48552
  • 基因名：
    NRIP1
  • 别名：
    NRIP 1 antibody; NRIP1 antibody; NRIP1_HUMAN antibody; Nuclear factor RIP 140 antibody; Nuclear factor RIP140 antibody; Nuclear receptor interacting protein 1 antibody; Nuclear receptor-interacting protein 1 antibody; Receptor interacting protein 140 antibody; Receptor-interacting protein 140 antibody; RIP 140 antibody; RIP140 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human RIP140 around the acetylation site of K158.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development.
  • 基因功能参考文献：
    1. Data suggests that NRIP1 is overexpressed both in skin and PBMCs of psoriasis patients and may be involved in the abnormal proliferation and apoptosis of keratinocytes. PMID: 27708240
    2. In skeletal muscle, imposed rest increased NRIP1 expression by 80%, and strength training increased expression by 25% compared to baseline. Following rest, NRIP1 expression became sensitive to insulin stimulation. After re-training, NRIP1 expression decreased. Interactome analysis showed significant proximity of NRIP1 interacting partners to the obesity network/module. PMID: 28656645
    3. Taken together, these results provide new insights into the mechanism of action of LCoR and RIP140 and highlight their strong interplay for the control of gene expression and cell proliferation in breast cancer cells. PMID: 28414308
    4. Study found low expression level of RIP140 in tumor-associated macrophages (TAM) of hepatocellular carcinoma (HCC) tissues and demonstrated that RIP140 expression in plays a role in the growth of hepatoma cells. PMID: 28393222
    5. results indicated that there was a significant association between migraine and gene-gene interaction among the CYP19A1, FSHR, ESR1 and NRIP1. PMID: 27019440
    6. Data indicate that nuclear receptor interacting protein 1 (NRIP1) is elevated in tumors compared to cancer adjacent normal tissue. PMID: 26492163
    7. NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/beta-catenin pathway. PMID: 26213846
    8. NRIP1 contributes to the mitochondrial dysfunction observed in DS. Furthermore, they suggest that the NRIP1-PGC-1alpha axe might represent a potential therapeutic target for restoring altered mitochondrial function in DS. PMID: 24698981
    9. RIP140 gene has been shown to be involved in the regulation of energy expenditure, in mammary gland development and intestinal homeostasis as well as in behavior and cognition PMID: 26116758
    10. Downregulation of RIP140 promoted the tumorigenicity of HCC cells in vitro. PMID: 25391428
    11. Data suggest that vitamin D receptor target genes (NRIP1; DUSP10, dual specificity phosphatase 10; THBD, thrombomodulin; TRAK1, trafficking protein kinesin binding 1) can be used as markers for individual's response to vitamin D3 supplements. PMID: 24975273
    12. RIP140 negatively regulated the macrophage expression of ATP-binding cassette transporters A1 and G1. PMID: 25616132
    13. The associations of rs2616984 in CSMD1 gene, putative associations of rs3131296 in NOTCH4 gene, and associations of rs2229741 of NRIP1 gene with Alzheimer's disease have been found in a Russian population. PMID: 25845235
    14. data suggest that RIP140 plays an important role in ERalpha-mediated transcriptional regulation in breast cancer and response to tamoxifen treatment PMID: 25145671
    15. In breast cancer cells, GSTP1 inhibits the expression of RIP140, a negative regulator of estrogen receptor alpha transcription, at both mRNA and protein levels. PMID: 25218501
    16. RIP140 stimulated APC transcription and inhibited beta-catenin activation and target gene expression. PMID: 24667635
    17. these data demonstrate the inhibitory effects of ERbeta on estrogen signaling in ovarian cancer cells and the key role that RIP140 plays in this phenomenon. PMID: 23885094
    18. genetic association studies in population of women in Spain: Data suggest an association between an SNP in NRIP1 (rs2229741) and age at menopause; thus, duration of fertility in women may have genetic determinants involved in estrogen metabolism. PMID: 23173577
    19. Increased RIP140 level may be closely associated with inflammation and disorder of lipid and glucose metabolism in diabetic patients. PMID: 22956256
    20. RIP140, a Janus metabolic switch involved in defense functions. PMID: 23241901
    21. this work identifies the RIP140 gene as a new transcriptional target of E2F1 which may explain some of the effect of E2F1 in both cancer and metabolic diseases. PMID: 22629304
    22. Highlight the importance of cross-regulation between AhR and ERalpha and a novel mechanism by which AhR controls, through modulating the recruitment of RIP140 to ERalpha-binding sites, the kinetics and magnitude of ERalpha-mediated gene stimulation. PMID: 22071320
    23. The fusion of NRIP1 with UHRF1 involved in the unbalanced translocation between chromosomes 19 and 21 in a patient with an ALL-positive for a t(9;22) translocation. PMID: 22285022
    24. Decreased RIP140 protein content not required for exercise and AMPK-dependent increases in skeletal muscle mitochondrial content. PMID: 21700896
    25. We demonstrate that NRIP is a novel binding protein for human papillomavirus 16 (HPV-16) E2 protein and directly interacts with the TAD of HPV-16 E2. PMID: 21543494
    26. This study shows that RIP140 is a regulator of the E2F pathway, which discriminates luminal- and basal-like tumors, emphasizing the importance of these regulations for a clinical cancer phenotype. PMID: 20410059
    27. RIP140 transgenic mice, expressing increased levels of RIP140 mRNA/protein in the heart, exhibit rapid and progressive postnatal cardiomyopathy leading to premature death predominantly owing to compromised energy production. PMID: 20083575
    28. Receptor-interacting protein 140 (RIP140) is a corepressor for nuclear receptors with an important role in the inhibition of energy expenditure. PMID: 19367438
    29. Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex. PMID: 20200160
    30. The RIP140 gene does not play a pivotal role in the process of ovulation, insulin resistance, or fat accumulation in women with PCOS. PMID: 19887821
    31. RIP140 may have a role in retinoic acid mediation of long-paced oscillations in retinoid receptor activity PMID: 19862326
    32. RIP140 has a role in binding to nuclear receptors, as well as additional functions mediated by the formation and intranuclear relocalization of a repressive protein complex PMID: 12773562
    33. there are four autonomous repression domains in the corepressor receptor interacting protein 140 PMID: 14736873
    34. RIP140 has a regulatory role in mediating anti-estrogenic effects of RA in estrogen-dependent breast cancer cells PMID: 15632153
    35. RIP140 differentially regulates ERR activity depending on the target sequence on the promoters. PMID: 16439465
    36. Receptor-interacting protein 140 is a repressor of the androgen receptor activity. PMID: 16527872
    37. RIP140 discriminates among different classes of retinoic acid target genes. RIP140 limits RA signaling & tumor-cell differentiation. RIP140 silencing sensitizes embryonal carcinoma cells to low doses of RA. PMID: 17880687
    38. The results presented here suggested the cooperative transcriptional regulation of estrogen signaling by FHL1 and RIP140. PMID: 19401155

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  • 亚细胞定位：
    Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
  • 数据库链接：

    HGNC: 8001

    OMIM: 602490

    KEGG: hsa:8204

    STRING: 9606.ENSP00000327213

    UniGene: Hs.155017