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EXOC1 Antibody

  • 中文名称：
    EXOC1兔多克隆抗体
  • 货号：
    CSB-PA007877GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NV70
  • 基因名：
    EXOC1
  • 别名：
    BM-012 antibody; exoc1 antibody; EXOC1_HUMAN antibody; Exocyst complex component 1 antibody; Exocyst complex component Sec3 antibody; FLJ10893 antibody; SEC3 antibody; SEC3 like 1 antibody; SEC3L1 antibody; SEC3P antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human EXOC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation.
  • 基因功能参考文献：
    1. rs13117307 is associated with cervical squamous cell carcinoma. rs13117307 SNP upregulated EXCO1 transcript levels in the non-cancerous cervical and in the cervical SCC tissue. PMID: 28694212
    2. Ezrin/Sec3 complexes are essential for MUC5AC secretion in NE-stimulated airway epithelial cells and that PIP2 is of critical importance in the formation of these complexes. PMID: 25591774
    3. This study portrayed the non-structural function of C protein that helped the flavivirus to nullify the antiviral activity of hSec3p by accelerating its degradation and facilitating efficient binding of elongation factor 1alpha with flaviviral RNA genome. PMID: 23522008
    4. This study identified human Sec3 exocyst protein (hSec3p) as a novel interacting partner of West Nile virus and Dengue virus C protein. PMID: 19889084
    5. Sec3 associates with a subset of Exocyst complexes that are enriched at desmosomes. PMID: 19889837
    6. The exocyst subunits Sec3 and Sec8 interact with the polarity protein IQGAP1 and that this interaction is triggered by active Cdc42 and RhoA, which are essential for matrix degradation. PMID: 18541705

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  • 亚细胞定位：
    Midbody, Midbody ring. Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族：
    SEC3 family
  • 数据库链接：

    HGNC: 30380

    OMIM: 607879

    KEGG: hsa:55763

    STRING: 9606.ENSP00000326514

    UniGene: Hs.269665