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  4. NLRP4 Antibody

NLRP4 Antibody

  • 中文名称：
    NLRP4兔多克隆抗体
  • 货号：
    CSB-PA123062
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA123062(NLRP4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA123062(NLRP4 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q96MN2
  • 基因名：
    NLRP4
  • 别名：
    Cancer/testis antigen 58 antibody; CLR19.5 antibody; CT58 antibody; FLJ32126 antibody; NACHT, leucine rich repeat and PYD containing 4 antibody; NACHT, LRR and PYD containing protein 4 antibody; NACHT, LRR and PYD domains-containing protein 4 antibody; NALP4_HUMAN antibody; NLR family, pyrin domain containing 4 antibody; NLRP4 antibody; Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 4 antibody; PAAD and NACHT containing protein 2 antibody; PAAD and NACHT-containing protein 2 antibody; PAN2 antibody; PYPAF4 antibody; PYRIN and NACHT-containing protein 2 antibody; PYRIN containing APAF1 like protein 4 antibody; PYRIN-containing APAF1-like protein 4 antibody; Ribonuclease inhibitor 2 antibody; RNH2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human NLRP4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
  • 基因功能参考文献：
    1. NLRP4 is an important mediator of cardiac remodeling in vitro and in vivo. PMID: 28486191
    2. This study describes conformational stability of native NLRP14 and mutants in their monomeric and dimeric states and compares them to NLRP4, a representative of a native pyrin domain fold. PMID: 25403012
    3. Structural and functional analysis of the NLRP4 pyrin domain. PMID: 22928810
    4. Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation. PMID: 22388039
    5. NLRP4 is recruited to and accumulates in bacteria-containing phagosomes and transiently dissociates from beclin1 following group A streptococcus infection, thereby controlling the autophagic flux crucial for cell-autonomous antibacterial resistance. PMID: 21209283

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  • 蛋白家族：
    NLRP family
  • 数据库链接：

    HGNC: 22943

    OMIM: 609645

    KEGG: hsa:147945

    STRING: 9606.ENSP00000301295

    UniGene: Hs.631533