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NRXN3 Antibody

  • 中文名称：
    NRXN3兔多克隆抗体
  • 货号：
    CSB-PA070298
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9HDB5
  • 基因名：
    NRXN3
  • 别名：
    NRXN3 antibody; KIAA0743 antibody; Neurexin-3-beta antibody; Neurexin III-beta) [Cleaved into: Neurexin-3-beta antibody; soluble form; Neurexin-3-beta antibody; C-terminal fragment antibody; NRXN3-CTF)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Neurexin IIIβ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis.
  • 基因功能参考文献：
    1. NRXN2 may play a part in early cortical synaptogenesis, but NRXNs could have diverse roles in development including axon guidance, and intercellular communication between proliferating cells and/or migrating neurons. PMID: 28013231
    2. The rare variants in NRXN3 were significantly associated with smoking status. PMID: 25450229
    3. This study confirmed the genetic heterogeneity of cluster headache, suggesting that a novel rearrangement involving NRXN3 gene might be related to cluster headache in a subset of cases PMID: 24469609
    4. The study showed that markers rs2217887 (NRXN3) showed weak associations. PMID: 24444492
    5. a positive association between Neurexin 3 and controls in the Han Chinese population, and genetic evidence to support the susceptibility of DEACMP PMID: 24265751
    6. Neurexin 3-alpha (NRXN3) is a synaptic cell-cell adhesion molecule involved in maintenance of neural connections (such as the maintenance of smoking behavior). PMID: 23909413
    7. By age 7, common variations in FTO, TMEM18 and NRXN3 influence the vulnerability to metabolic complications of sleep deprivation. PMID: 22391885
    8. Our findings suggested that NRXN3 might represent a major susceptibility gene for schizophrenia PMID: 23306218
    9. the study finds preliminary evidence for the association of NRXN3 with Borderline Personality Disorder phenotypes. The strongest association with positive screening for BPD was found for SNP rs10083466. PMID: 23245376
    10. FoxQ1 promotes glioma cell proliferation and migration by down-regulation of NRXN3 expression. PMID: 23383267
    11. NRXN3 polymorphisms play a role in susceptibility to smoking behavior and are strongly implicated in human genetic vulnerability to addictive behaviors. PMID: 22716474
    12. Association of the Graves disease phenotype with two markers, rs12147587 and rs2284720, located within the NRXN3 and TSHR genes, respectively. PMID: 23118423
    13. N-terminal sequencing of rat neurexin III alpha provides evidence for signal peptide PMID: 9856994
    14. N-terminal sequencing of cow neurexin III beta provides evidence for signal peptide PMID: 8163501
    15. alpha- and gamma-secretases can sequentially process NRXN3beta, leading to the formation of two final products, an approximately 80-kDa N-terminal extracellular domain of Neurexin-3beta (sNRXN3beta) and an approximately 12-kDa C-terminal intracellular NRXN3beta domain (NRXN3beta-ICD) PMID: 21084300
    16. Six NRXN3 polymorphisms were genotyped: rs983795, rs11624704, rs917906, rs1004212, rs10146997 and rs8019381 associated with impulsivity and substance abuse. PMID: 21676558
    17. NRXN3 single nucleotide polymorphism rs10146997 was significantly (P = 0.0445) associated with higher risk of breast cancer development (OR = 0.66 (95% CI 0.44-0.99)). PMID: 21688152
    18. Index cases of autism spectrum were clinically characterized who have rare microdeletions at 14q24.3-31.1, a region that overlaps exons of the alpha and/or beta isoforms of NRXN3. PMID: 22209245
    19. Our results reveal that menopause influences the adipose tissue expression of many genes, especially of neurexin 3, metallothionein 1E, and keratyn 7, which are associated with the alteration of several key biological processes. PMID: 21358552
    20. central obesity-associated variants in LYPLAL1, NRXN3, MSRA, and TFAP2B PMID: 21674055
    21. Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia. PMID: 19658047
    22. Identification and characterization of heart-specific splicing of neurexin 3 mRNA PMID: 12379233
    23. details of NRXN3's gene structure and variants, and association of NRXN3 SNPs with alcohol dependence PMID: 17804423
    24. Variants in NRXN3 are associated with waist circumference, body mass index and obesity. PMID: 19557197

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Neurexin family
  • 组织特异性：
    Expressed in the blood vessel walls (at protein level).
  • 数据库链接：

    HGNC: 8010

    OMIM: 600567

    KEGG: hsa:9369

    UniGene: Hs.368307