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OSBPL3 Antibody

  • 中文名称：
    OSBPL3兔多克隆抗体
  • 货号：
    CSB-PA017249GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H4L5
  • 基因名：
    OSBPL3
  • 别名：
    DKFZp667P1518 antibody; KIAA0704 antibody; MGC21526 antibody; ORP 3 antibody; ORP-3 antibody; ORP3 antibody; OSBL3_HUMAN antibody; OSBP related protein 3 antibody; OSBP-related protein 3 antibody; OSBP3 antibody; Osbpl3 antibody; Oxysterol binding protein 3 antibody; Oxysterol binding protein like 3 antibody; Oxysterol binding protein related protein 3 antibody; Oxysterol-binding protein-related protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human OSBPL3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol.
  • 基因功能参考文献：
    1. It indicates that VAPB along with ORP3 plays a central role in maintenance of the intracellular PtdIns4P gradient. PMID: 26812496
    2. phosphorylation of ORP3 controls its association with VAPA. Furthermore, ORP3-VAPA complexes stimulate R-Ras signaling. PMID: 25447204
    3. The intracellular targeting determinants of oxysterol binding protein (OSBP)-related protein 3 (ORP3) were studied using a series of truncated and point mutated constructs. PMID: 16143324
    4. The present findings demonstrate a new function of ORP3 as part of the machinery that controls the actin cytoskeleton, cell polarity and cell adhesion. PMID: 18270267
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell projection, filopodium tip. Nucleus membrane; Peripheral membrane protein.
  • 蛋白家族：
    OSBP family
  • 组织特异性：
    Expressed in a subset of small lymphocytes (at protein level). Expressed at high concentration in kidney, lymph node and thymus. Expressed at moderate concentration in stomach, jejunum, ileum, appendix, spleen, leukocytes, trachea, lung and thyroid gland.
  • 数据库链接：

    HGNC: 16370

    OMIM: 606732

    KEGG: hsa:26031

    STRING: 9606.ENSP00000315410

    UniGene: Hs.520259