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  4. PAGE4 Antibody

PAGE4 Antibody

  • 中文名称：
    PAGE4兔多克隆抗体
  • 货号：
    CSB-PA900712
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA900712(PAGE4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O60829
  • 基因名：
    PAGE4
  • 别名：
    PAGE4 antibody; GAGEC1 antibody; JM27P antigen family member 4 antibody; PAGE-4 antibody; G antigen family C member 1 antibody; PAGE-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human PAGE4
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN. Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway.
  • 基因功能参考文献：
    1. phosphorylation of PAGE4 leads to conformational shifts PMID: 26242913
    2. PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1. PMID: 24559171
    3. Data suggest that disrupting prostate-associated gene 4 (PAGE4)/c-Jun interaction using small molecules could be a novel strategy to treat prostate cancer. PMID: 24263171
    4. Dysregulation of epithelial PAGE4 modulates AR signaling. PMID: 22885105
    5. PAGE4 is a highly intrinsically disordered protein with an anti-apoptotic function PMID: 21357425
    6. PAGE4 mRNA is expressed only in the cytoplasm of epithelial cells of normal and prostate-cancer specimens PMID: 12489849
    7. These results suggest that GAGE gene might have an important role in the development and progression of intestinal type of stomach cancer and the detection of GAGE mRNA may be eligible to the panel of molecular markers for aggressive behavior. PMID: 15362791

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Mitochondrion.
  • 蛋白家族：
    GAGE family
  • 组织特异性：
    Expressed at basal lvels in the adult normal prostate gland but is highly up-regulated in the fetal prostate and prostate cancer cells. Preferentially expressed in normal male and female reproductive tissues, testis, fallopian tube, uterus, and placenta,
  • 数据库链接：

    HGNC: 4108

    OMIM: 300287

    KEGG: hsa:9506

    STRING: 9606.ENSP00000218068

    UniGene: Hs.441038