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  4. Recombinant Human G antigen family C member 1 (PAGE4)

Recombinant Human G antigen family C member 1 (PAGE4)

  • 中文名称：
    人PAGE4重组蛋白
  • 货号：
    CSB-YP017394HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PAGE4重组蛋白
  • 货号：
    CSB-EP017394HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PAGE4重组蛋白
  • 货号：
    CSB-EP017394HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PAGE4重组蛋白
  • 货号：
    CSB-BP017394HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PAGE4重组蛋白
  • 货号：
    CSB-MP017394HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PAGE4
  • Uniprot No.：
  • 别名：
    PAGE4; GAGEC1; JM27P antigen family member 4; PAGE-4; G antigen family C member 1; PAGE-1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-102
  • 氨基酸序列
    MSARVRSRSR GRGDGQEAPD VVAFVAPGES QQEEPPTDNQ DIEPGQEREG TPPIEERKVE GDCQEMDLEK TRSERGDGSD VKEKTPPNPK HAKTKEAGDG QP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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靶点详情

  • 功能：
    Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN. Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway.
  • 基因功能参考文献：
    1. phosphorylation of PAGE4 leads to conformational shifts PMID: 26242913
    2. PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1. PMID: 24559171
    3. Data suggest that disrupting prostate-associated gene 4 (PAGE4)/c-Jun interaction using small molecules could be a novel strategy to treat prostate cancer. PMID: 24263171
    4. Dysregulation of epithelial PAGE4 modulates AR signaling. PMID: 22885105
    5. PAGE4 is a highly intrinsically disordered protein with an anti-apoptotic function PMID: 21357425
    6. PAGE4 mRNA is expressed only in the cytoplasm of epithelial cells of normal and prostate-cancer specimens PMID: 12489849
    7. These results suggest that GAGE gene might have an important role in the development and progression of intestinal type of stomach cancer and the detection of GAGE mRNA may be eligible to the panel of molecular markers for aggressive behavior. PMID: 15362791

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Mitochondrion.
  • 蛋白家族：
    GAGE family
  • 组织特异性：
    Expressed at basal lvels in the adult normal prostate gland but is highly up-regulated in the fetal prostate and prostate cancer cells. Preferentially expressed in normal male and female reproductive tissues, testis, fallopian tube, uterus, and placenta,
  • 数据库链接：

    HGNC: 4108

    OMIM: 300287

    KEGG: hsa:9506

    STRING: 9606.ENSP00000218068

    UniGene: Hs.441038