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  4. PTPN23 Antibody

PTPN23 Antibody

  • 中文名称：
    PTPN23兔多克隆抗体
  • 货号：
    CSB-PA019037GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H3S7
  • 基因名：
    PTPN23
  • 别名：
    DKFZP564F0923 antibody; EC 3.1.3.48 antibody; HD PTP antibody; HD-PTP antibody; His domain containing protein tyrosine phosphatase antibody; His domain protein tyrosine phosphatase antibody; His domain-containing protein tyrosine phosphatase antibody; KIAA1471 antibody; Protein tyrosine phosphatase non receptor type 23 antibody; Protein tyrosine phosphatase TD 14 antibody; Protein tyrosine phosphatase TD14 antibody; PTN23_HUMAN antibody; PTP TD14 antibody; PTP-TD14 antibody; PTPN 23 antibody; PTPN23 antibody; Tyrosine protein phosphatase non receptor type 23 antibody; Tyrosine-protein phosphatase non-receptor type 23 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PTPN23
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
  • 基因功能参考文献：
    1. Mutations in PTPN23 gene is associated with developmental and epileptic encephalopathy. PMID: 29090338
    2. HD-PTP/PTPN23 as a prominent haploinsufficient tumor suppressor gene preventing tumor progression through control of integrin trafficking. PMID: 27210750
    3. the underlying mechanism of PTPN23 function in breast tumorigenesis as that of a key phosphatase that normally suppresses the activity of FYN PMID: 29066500
    4. The role of HD-PTP/PTPN23 in cancer and tumorigenesis is reviewed. PMID: 28620046
    5. Results present crystal structures of the coiled-coil domain of the HD-PTP phosphatase and its complex with UBAP1. The coiled-coil domain adopts an unexpected open and rigid conformation. The HD-PTP:UBAP1 structure identifies the molecular determinants of the interaction and provides a molecular basis for the specific functional cooperation between HD-PTP and UBAP1. PMID: 27839950
    6. HD-PTP acts as an alternative to ESCRT-II and VPS20/CHMP6 as a link between the ESCRT-I and those ESCRT-III protein(s) necessary for ILV formation. PMID: 26221024
    7. Data indicate a regulatory function of non-receptor-type tyrosine phosphatase PTPN23 in maintaining a highly phosphorylated state of survival motor neuron complex protein SMN. PMID: 25392300
    8. PTPN23 is a tumor suppressor and that repression of PTPN23 expression by miR-142-3p plays an important role in the pathogenesis of testicular germ cell tumors. PMID: 23843459
    9. The ESCRT accessory protein HD-PTP/PTPN23 associates with epidermal growth factor receptor (EGFR) and combines with the deubiquitinating enzyme UBPY/USP8 to transfer EGFR from ESCRT-0 to ESCRT-III and drive EGFR sorting to intralumenal vesicles. PMID: 23477725
    10. our findings suggest an evolutionarily conserved function of HDPTP-Rab4 in the regulation of endocytic trafficking, cell adhesion and migration PMID: 22825871
    11. HD-PTP degradation by calpains might result in the acquisition of a more aggressive phenotype in neoplastic cells. PMID: 22510412
    12. loss of PTPN23 may increase the activity of SRC and the phosphorylation status of the E-cadherin/beta-catenin signaling complex to promote tumor growth and invasive behavior in breast cancer PMID: 21724833
    13. Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL PMID: 21179510
    14. These results suggest that HD-PTP amounts might be regulated both at the transcriptional and post-transcriptional levels. PMID: 16408268
    15. data suggest that HD-PTP might participate in modulating endothelial response to angiogenic factors and play a role in regulating the complex events leading to the formation of new vessels PMID: 16720300
    16. We suggest that HD-PTP contributes to the regulation of endothelial motility by modulating the tyrosine phosphorylation of FAK. PMID: 17959146
    17. contributes to the regulation of endothelial migration; may play a role in angiogenesis PMID: 18762272
    18. in Epidermal Growth Factor (EGF) stimulated cells, Src binds to and phosphorylates HD-PTP on tyrosine residues PMID: 18835089
    19. demonstrate that HD-PTP is a catalytically inactive protein tyrosine phosphatase. As such, we identify one residue involved in its inactivation and show that colony growth reduction activity is independent of its PTP activity status in cancer cell lines PMID: 19340315

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class subfamily
  • 数据库链接：

    HGNC: 14406

    OMIM: 606584

    KEGG: hsa:25930

    STRING: 9606.ENSP00000265562

    UniGene: Hs.25524