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PTS Antibody

  • 中文名称：
    PTS兔多克隆抗体
  • 货号：
    CSB-PA019073GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q03393
  • 基因名：
    PTS
  • 别名：
    6 pyruvoyl tetrahydrobiopterin synthase antibody; 6 pyruvoyl tetrahydropterin synthase antibody; 6 pyruvoyltetrahydropterin synthase antibody; 6-pyruvoyl tetrahydrobiopterin synthase antibody; EC 4.2.3.12 antibody; FLJ97081 antibody; OTTHUMP00000235385 antibody; PTP synthase antibody; PTPS antibody; PTPS_HUMAN antibody; PTS antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PTS
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
  • 基因功能参考文献：
    1. Severe neurological impairment from BH4 deficiency could be prevented by newborn screening for hyperphenylalaninemia (HPA) and proper metabolic management. PMID: 19830588
    2. A total of 43 mutations were identified in the PTS gene in a screen of East Asian populations, comprising 22 previously reported mutations and 21 new discovered mutations. PMID: 22237589
    3. The mutant characterization of PTPS gene was coincident with other early studies in Chinese. The novel mutation L127F was considered as a pathogenetic mutation and associated with severe clinical phenotype. PMID: 18505119
    4. Our data show that PTPS induction is necessary for optimized BH4 synthesis in cytokine-stimulated human coronary artery endothelial cells and point to IL-1beta as a leading cytokine in this process. PMID: 14551150
    5. Hyperphenylalaninemia may be caused by deficiency of Phe hydroxylase or by deficiency of co-factor BH(4). PMID: 16086286
    6. Human PTS was efficiently expressed in noradrenergic regions but only in a small number of dopaminergic neurons. PMID: 16135092
    7. Expression of PTS was significantly decreased in PD cases. PMID: 17270157
    8. mutational analysis in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthesis deficiency PMID: 11438997

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  • 相关疾病：
    Hyperphenylalaninemia, BH4-deficient, A (HPABH4A)
  • 蛋白家族：
    PTPS family
  • 数据库链接：

    HGNC: 9689

    OMIM: 261640

    KEGG: hsa:5805

    STRING: 9606.ENSP00000280362

    UniGene: Hs.503860